Objective  To investigate the changes of hematological examination indexes and the incidence of pregnancy associated diseases in women with advanced maternal age in different periods of gestation.

  Methods  A total of 100 delivery women with advanced maternal age who received prenatal examination in our hospital were randomly selected as the study group. A total of 100 delivery women with proper age in the same period in our hospital were selected as the control group. The hematology test indicators in the early, middle and late stages of pregnancy were detected and compared, and the incidence of pregnancy associated diseases was statistically analyzed.

  Results  The triglyceride(TG), total cholesterol (TC), low density lipoprotein cholesterol(LDL-C) and thyroid stimulating hormone(TSH) levels in the study group were higher at middle and late stages of pregnancy than those in the control group (P < 0.05), and the levels of high density lipoprotein cholesterol(HDL-C), free tri-iodothyronine (FT₃) and free thyroxine(FT₄) were lower than those in the control group (P < 0.05). Fasting blood glucose(FBG) level in the study group was higher than that in the control group (P < 0.05). The incidence of pregnancy associated diseases in the study group was higher than that in the control group (P < 0.05).

  Conclusion  Hematology index test should be strengthened to guide pregnancy management and control the occurrence of pregnancy associated diseases for advanced maternal age cases during pregnancy.