Relationship between intima-media thickness, stenosis severity and carotid atherosclerosisin patients with calcification of cardiac valveby cardiac color Doppler ultrasound
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摘要:目的 探讨心脏彩超检测心脏瓣膜病钙化患者颈动脉内膜中层厚度(IMT)、管腔狭窄程度与颈动脉粥样硬化的关系。方法 选择老年钙化性心脏瓣膜病(SCVHD)合并颈动脉粥样硬化症(CAS)患者共90例作为研究组，同期选择单纯CAS不合并SCVHD的患者60例作为对照组，非心血管疾病患者60例作为健康组。比较3组患者瓣膜厚度、IMT以及狭窄程度，并分析IMT和狭窄程度与瓣膜厚度的相关性，使用Logistic多元回归分析法分析其与瓣膜厚度的关系。结果 3组瓣膜厚度、IMT及狭窄程度有显著差异(P < 0.05), 对照组各项指标显著高于健康组(P < 0.05), 研究组显著高于对照组和健康组(P < 0.05); IMT以及狭窄程度与瓣膜厚度呈正相关关系(P < 0.05); CAS患者IMT和管腔狭窄程度是SCVHD的危险因素(P < 0.05)。结论 SCVHD合并CAS患者的IMT以及狭窄程度水平更高，可作为CAS患者并发SCVHD的独立判断因素。
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关键词:
- 老年钙化性心脏瓣膜病 /
- 颈动脉粥样硬化症 /
- 颈动脉内膜中层厚度 /
- 心脏彩超
Abstract:Objective To investigate the relationship between intima-media thickness(IMT), stenosis severity and carotid atherosclerosis in patients with calcification of cardiac valve by cardiac color Doppler ultrasound.Methods A total of 90 patients with senile calcific valve heart disease (SCVHD) and coronary atherosclerosis(CAS) were enrolled in the study group were selected as study group. In the same period, 60 patients with CAS alone without SCVHD were as control group, and 60 patients with non-cardiovascular disease were included as the healthy group. The valve thickness, IMT, and stenosis were compared between the three groups, and the correlation between MT, stenosis and valve thickness was analyzed. Logistic multiple regression analysis was used to analyze its relationship with valve thickness.Results There were significant differences in valve thickness, IMT, and stenosis in the three groups (P < 0.01). The indexes of the control group were significantly higher than the healthy group (P < 0.01), and the study group weresignificantly higher than that of the control group and the healthy group (P < 0.01). There was a positive correlation between IMT, stenosis and valve thickness (P < 0.01). The IMT and stenosis degree of CAS patients were risk factors for SCVHD (P < 0.01).Conclusion SCVHD combined with CAS patients had higher IMT and stenosis severity, which can be used as an independent factor for SCVHD patients with CAS. -
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表 1 3组瓣膜厚度、IMT以及狭窄程度比较(x±s)
组别 n 瓣膜厚度/mm IMT/mm 狭窄程度/% 研究组 90 3.75±0.73*# 1.84±0.32*# 62.57±8.21*# 对照组 60 2.24±0.62* 1.43±0.24* 38.69±6.33* 健康组 60 1.35±0.46 0.84±0.11 19.53±2.37 IMT: 颈动脉内膜中层厚度。与健康组比较, *P < 0.01; 与对照组比较, #P < 0.01。 
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表 2 SCVHD的多因素Logistic回归分析
影响因素 β S. E. Wald χ2 P OR 95%CI IMT 0.614 0.012 10.853 0.001 1.089 1.017~1.160 狭窄程度 0.633 0.007 11.275 0.001 1.057 1.009~1.127 SCVHD: 老年钙化性心脏瓣膜病; IMT: 颈动脉内膜中层厚度。
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