Clinical effect of Qingfei Decoction for patients with acute exacerbation of chronic obstructive pulmonary disease differentiated as phlegm-heat accumulation in lung
-
摘要:目的 观察清肺汤对慢性阻塞性肺病急性加重期(AECOPD)痰热蕴肺型患者的临床疗效。方法 将72例AECOPD痰热蕴肺型患者随机分为治疗组和对照组，各36例。对照组给予抗炎、解痉、化痰等西医常规治疗，治疗组在对照组基础上加服清肺汤, 1剂/d。2组疗程均为14 d。观察2组治疗前后临床症状、体征、肺功能的改善情况及安全性评估。结果 治疗组症状总积分显著优于对照组; 2组患者治疗后临床症状均有显著改善，但治疗组改善情况优于对照组(P < 0.05); 治疗组综合治疗疗效优于对照组，差异有统计学意义(P < 0.01); 2组患者治疗前后组间和组内肺功能变化比较差异无统计学意义(P>0.05)。结论 清肺汤对AECOPD痰热蕴肺型患者临床疗效确切，能改善患者健康状态，提高活动耐力。Abstract:Objective To observe the clinical effect of Qingfei Decoction for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD)differentiated as phlegm-heat accumulation in lung.Methods A total of 72 AECOPD patients with phlegm-heat accumulation were randomly divided into treatment group and control group, with 36 cases per group. The control group was given routine treatment, such as anti-inflammation, spasmolysis, and phlegm relieving, and the treatment group was additionally given Qingfei Decoction on the basis of the control group for 1 dose per day. The course of treatment of both groups was 14 days. The clinical symptoms, signs, improvement of lung function and safety evaluation of the two groups before and after treatment were observed.Results The total scores of symptoms in the treatment group were significantly better than of the control group; the clinical symptoms of the two groups were significantly improved after treatment, but the improvement of the treatment group was better than that of the control group (P < 0.05); the treatment group had better comprehensive treatment efficacy than the control group(P < 0.01); there were no between-group and intra-group significant differences in lung function before and after treatment (P>0.05).Conclusion Qingfei Decoction has a definite clinical effect for AECOPD patients differentiated as phlegm-heat accumulating, which can improve their health status and activity endurance.
-
-
表 1 2组临床症状及体征量化评分比较(x±s)
分 临床症状 时点 n 治疗组 对照组 咳嗽 治疗前 36 2.43±0.48 2.67±0.32 治疗后 36 0.67±0.40**# 0.9±0.35** 咳痰 治疗前 36 2.54±0.40 2.56±0.35 治疗后 36 0.58±0.54**# 1.86±0.56* 喘息 治疗前 36 2.53±0.41 2.64±0.47 治疗后 36 1.12±0.53**# 1.28±0.45** 啰音 治疗前 36 2.15±0.45 2.25±0.64 治疗后 36 0.46±0.45** 1.26±0.36** 发热 治疗前 36 2.56±0.22 2.69±0.18 治疗后 36 0.23±0.22** 0.28±0.20** 与治疗前比较, *P < 0.05, **P < 0.01; 与对照组比较, #P < 0.05。 
下载: 导出CSV
表 2 2组治疗前后肺功能变化情况比较(x±s)
% 组别 时点 n FEV1% FEV1/FVC 治疗组 治疗前 36 60.26±9.08 57.86±9.08 治疗后 36 61.28±10.56 58.23±10.45 对照组 治疗前 36 59.45±10.56 58.68±9.63 治疗后 36 60.56±9.56 59.45±10.52 FEV1%: 1秒钟用力呼气量占预计值的百分比; FEV1/FVC: 1秒钟用力呼气量与用力肺活量占预计值的百分比。
下载: 导出CSV
-
[1] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南[J]. 中华内科杂志, 2002, 41(9): 640-646. doi: 10.3760/j.issn:0578-1426.2002.09.037 [2] 中华中医药学会内科分会肺系病专业委员会. 慢性阻塞性肺疾病中医证候诊断标准(2011版)[J]. 中医杂志, 2012, 53(2): 177-178. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ201202037.htm [3] 范良, 卢保强, 郑肇良, 等. 中药沐足治疗慢性阻塞性肺疾病稳定期的临床研究[J]. 中国中医基础医学杂志, 2016, 22(8): 1074-1076. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJC201608025.htm [4] 陈学昂, 李素云, 王明航. 痰热证与慢性阻塞性肺疾病急性加重的相关性研究[J]. 中医研究, 2016, 29(11): 75-77. doi: 10.3969/j.issn.1001-6910.2016.11.30 [5] 李建生, 李彬, 余学庆, 等. 清热化痰方药治疗慢性阻塞性肺疾病急性加重期痰热壅肺证69例临床观察[J]. 中医杂志, 2011, 52(3): 203-207. doi: 10.3969/j.issn.0411-8421.2011.03.039 [6] 彭文波, 李淑芳, 熊旭, 等. 慢性阻塞性肺疾病急性发作期实证证型与客观指标的相关性探讨[J]. 中国中医急症, 2010, 19(3): 435-437. doi: 10.3969/j.issn.1004-745X.2010.03.041 [7] 周玉岩, 乔红杰, 李春玲, 等. 金荞麦提取物体外抗菌活性研究[J]. 中兽医医药杂志, 2009, 28(5): 44-46. doi: 10.3969/j.issn.1000-6354.2009.05.018 [8] 赵子剑, 郭胜雄, 刘译, 等. 鱼腥草药理作用的文献再评价[J]. 陕西中医学院学报, 2010, 33(1): 63-65. https://www.cnki.com.cn/Article/CJFDTOTAL-SXXY201001041.htm [9] 金鹏, 许海舰, 徐宝欣, 等. 黄芩苷研究现状及其镁盐研究前景[J]. 中国实验方剂学杂志, 2017, 23(20): 228-234. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX201720040.htm [10] 吴震东, 李可坚. 清金化痰汤合杏丁注射液治疗慢性阻塞性肺疾病急性期疗效观察[J]. 现代中西医结合杂志, 2007, 16(24): 3500-3501. doi: 10.3969/j.issn.1008-8849.2007.24.032 [11] 陆益民, 奚肇庆, 虞乐群, 等. 中西医结合治疗老年慢性阻塞性肺疾病急性发作期的疗效观察[J]. 中国老年学杂志, 2013, 33(2): 296-298. doi: 10.3969/j.issn.1005-9202.2013.02.022 [12] 吕建珍, 邓家刚. 苦杏仁苷的药理作用研究进展[J]. 现代药物与临床杂志, 2012, 27(5): 530-535. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW201205026.htm [13] 左军, 尹柏坤, 胡晓阳. 桔梗化学成分及现代药理研究进展[J]. 辽宁中医药大学学报, 2019, 21(1): 113-116. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB201901034.htm [14] 张明发, 沈雅琴. 半夏提取物抗菌抗炎及其抗肿瘤作用的研究进展[J]. 抗感染药学, 2017, 14(6): 1089-1094. https://www.cnki.com.cn/Article/CJFDTOTAL-KGYY201706005.htm [15] 沈蔚, 任晓婷, 张建, 等. 芦根多糖的提取及其抗氧化活性的研究[J]. 时珍国医国药, 2010, 21(5): 1078-1080. doi: 10.3969/j.issn.1008-0805.2010.05.023 -
期刊类型引用(2)
1. 代晓娟，温凯，许可. 平鳍式种植体与螺纹式种植体对口腔种植患者经济负担与并发症的影响. 中国美容医学. 2023(03): 144-147 . 
百度学术
2. 王雪红，陈彩云，李莹. 低能量激光疗法治疗种植体周围炎患者的临床效果. 现代养生. 2023(17): 1288-1290 . 百度学术
其他类型引用(1)
表(2)
计量
- 文章访问数:
- HTML全文浏览量:
- PDF下载量:
- 被引次数: 3
苏公网安备 32100302010246号