沈阳地区幽门螺杆菌感染现状调查分析

郭颖; 裴冬梅; 张耐思

doi:10.7619/jcmp.201913028

沈阳地区幽门螺杆菌感染现状调查分析

中国医科大学附属盛京医院全科医学科, 辽宁沈阳, 110004

基金项目:

中国医科大学“十三五”医学教育科学研究课题 YDJK2016008

详细信息

通讯作者:
裴冬梅, E-mail: peidm@sj-hospital.org

中图分类号: R573
计量
- 文章访问数: 336
- HTML全文浏览量: 151
- PDF下载量: 6
出版历程
- 收稿日期: 2019-05-14
- 录用日期: 2019-06-21
- 网络出版日期: 2021-02-23
- 发布日期: 2019-07-14

Investigation on infection status of population with Helicobacter pylori infection in Shengyang region

Department of General Medicine, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning, 110004

摘要

摘要:
目的了解沈阳地区人群幽门螺杆菌(Hp)感染现状，并分析其感染特点及其相关因素。
方法收集2018年1—12月于本院体检中心检测Hp的人群相关资料。根据年龄将患者分为3组，青年组(17~29岁)、中年组(30~59岁)和老年组(≥60岁); 根据感染情况分为阳性组和阴性组。分析不同性别、不同年龄段感染的特点及Hp感染与血糖、血脂间的相关性。
结果 11 775例患者进行了¹⁴C尿素呼气试验检测, 总感染率为30.99%。阳性组中男性共2 376例，感染率为65.11%; 女性共1 273例，感染率为34.89%, 差异有统计学意义(P < 0.05)。青年组的Hp阳性和阴性率与中年组、老年组比较，差异有统计学意义(P < 0.01), 而中年组和老年组比较，差异无统计学意义(P>0.05); Hp阳性组的血糖、甘油三酯及低密度胆固醇水平均高于Hp阴性组，差异有统计学意义(P < 0.05), 而2组总胆固醇和高密度胆固醇差异无统计学意义(P>0.05)。
结论 Hp阳性感染与年龄、性别、血糖、甘油三酯及低密度胆固醇有关，与总胆固醇和高密度胆固醇无显著相关性。
- 幽门螺杆菌 /
- 血糖 /
- 血脂 /
- 总胆固醇 /
- 高密度胆固醇
Abstract:
Objective To investigate the infection status of Helicobacter pylori(Hp) infection in Shenyang region, and to analyze its infection characteristics and related factors.
Methods The data of population with Hp infection detected in our physical examination center from January to December 2018 were retrospectively studied. These patients were divided into three groups according to varied ages: the youth group, the middle-aged group and the elderly group, and two groups according to the infection conditions: Hp-positive group and negative group. The characteristics of infections in varied gender and age groups were analyzed, and relationship between Hp infection and blood glucose, blood lipids were observed.
Results ¹⁴C urea exhalation test was carried out in 11 775 people, with total infection rate of 30.99%. In the positive group, there were 2 376 male cases, and 1 273 female cases, with the infection rate of 65.11%, 34.89%, respectively, the differences were statistically significant (P < 0.05). The positive and negative rates of Hp in the young group showed significant differences compared to those in the middle-aged and elderly groups (P < 0.01), but no significant differences were seen between the middle-aged group and the elderly group (P>0.05). The blood glucose, triglyceride and low-density cholesterol levels in Hp-positive group were higher than those in Hp-negative group (P < 0.05), but there was no significant between-group differences in total cholesterol and high-density cholesterol(P>0.05).
Conclusion Hp positive infection is related to age, sex, blood glucose, triglyceride and low-density cholesterol, but has no significant correlation with total cholesterol and high-density cholesterol.
- Helicobacter pylori /
- blood glucose /
- blood lipids /
- total cholesterol /
- high density cholesterol

HTML全文

表 1 Hp和年龄相关性[n(%)]

组别	n	Hp阳性	Hp阴性
青年组	1 003	243(24.23)^**	760(75.77)^**
中年组	8 898	2 823(31.73)	6 075(68.27)
老年组	1 874	583(31.11)	1 291(68.89)
与中年组、老年组比较, **P < 0.01。

下载: 导出CSV

表 2 Hp与血糖、血脂的相关性

项目	Hp阴性组	Hp阳性组
血糖/(mmol/L)	5.25(4.91, 5.71)	5.29(4.94, 5.75)^*
总胆固醇/(mmol/L)	4.81(4.25, 5.44)	4.88(4.32, 5.48)
甘油三酯/(mmol/L)	1.32(0.87, 2.04)	1.34(0.90, 2.03)^*
高密度胆固醇/(mmol/L)	1.22(1.02, 1.49)	1.20(1.01, 1.46)
低密度胆固醇/(mmol/L)	2.98(2.49, 3.55)	3.07(2.56, 3.60)^*
M(Q1, Q3)代表中位数。

下载: 导出CSV

参考文献(31)

[1]	McGuigan A, Kelly P, Turkington R C, et al. Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes[J]. World J Gastroenterol, 2018, 24(43): 4846-4861. doi: 10.3748/wjg.v24.i43.4846
[2]	白焕焕. 肠内营养对溃疡性结肠炎患者的疗效评价及生活质量评估[D]. 长春: 吉林大学, 2016.
[3]	Khademi F, Poursina F, Hosseini E, et al. Helicobacter pylori in Iran: A systematic review on the antibiotic resistance[J]. Iran J Basic Med Sci, 2015, 18(1): 2-7. http://pubmedcentralcanada.ca/pmcc/articles/PMC4366738/
[4]	Flores-Treviño C E, Urrutia-Baca V H, Gómez-Flores R, et al. Molecular detection of Helicobacter pylori based on the presence of cagA and vacA virulence genes in dental plaque from patients with periodontitis[J]. J Dent Sci, 2019, 14(2): 163-170. doi: 10.1016/j.jds.2019.01.010
[5]	王欢, 熊梅, 付丽, 等. 2型糖尿病患者颈动脉粥样硬化与幽门螺杆菌感染的相关性研究[J]. 临床和实验医学杂志, 2017, 16(11): 1116-1119. doi: 10.3969/j.issn.1671-4695.2017.11.025
[6]	卢学勉. 2型糖尿病患者心脑血管病变和幽门螺杆菌感染之间的关系[C]. 杭州: 浙江省医学会内分泌学分会: 浙江省科学技术协会, 2005.
[7]	Zhao Z W, Kang W M, Ma Z Q, et al. Gastric cancer with severe immune thrombocytopenia: A case report[J]. World J Clin Cases, 2018, 6(15): 1024-1028. doi: 10.12998/wjcc.v6.i15.1024
[8]	Rahmani Y, Mohammadi S, Babanejad M, et al. Association of helicobacter pylori with presence of myocardial infarction in iran: a systematic review and meta-analysis[J]. Ethiop J Health Sci, 2017, 27(4): 433-440. doi: 10.4314/ejhs.v27i4.15
[9]	Bravo D, Hoare A, Soto C, et al. Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects[J]. WJG, 2018, 24(28): 3071-3089. doi: 10.3748/wjg.v24.i28.3071
[10]	帕孜热·赛福丁. 非酒精性脂肪肝与幽门螺杆菌感染的相关性分析[D]. 乌鲁木齐: 新疆医科大学, 2016.
[11]	于晓辉, 马骥, 张久聪, 等. 健康成年人幽门螺杆菌感染特点分析[J]. 西部中医药, 2018, 31(11): 62-64.
[12]	Vaziri F, Tarashi S, Fateh A, et al. New insights of Helicobacter pylori host-pathogen interactions: The triangle of virulence factors, epigenetic modifications and non-coding RNAs[J]. World J Clin Cases, 2018, 6(5): 64-73. doi: 10.12998/wjcc.v6.i5.64
[13]	Sugano K, Tack J, Kuipers E J, et al. Kyoto global consensus report on Helicobacter pylori gastritis[J]. Gut, 2015, 64(9): 1353-1367. doi: 10.1136/gutjnl-2015-309252
[14]	张明磊. 沈阳地区幽门螺杆菌流行病学调查研究[C]. 宁波: 中国微生物学会临床微生物学专业委员会, 2012.
[15]	文婷婷, 陈亚芳, 戴娜, 等. 幽门螺杆菌感染临床检测方法及应用进展[J]. 陕西医学杂志, 2018, 47(12): 1670-1673. https://www.cnki.com.cn/Article/CJFDTOTAL-SXYZ201812045.htm
[16]	唐海灵, 庄坤, 闫媛, 等. 6085例人群中幽门螺杆菌感染的特征分析[J]. 中国卫生检验杂志, 2017, 27(24): 3620-3621.
[17]	Kimura T, Nishikawa T. A biomarker panel: an additional resource in acute stroke evaluation[J]. Minerva Anestesiol, 2013, 79(7): 711-712. http://europepmc.org/abstract/MED/23558768
[18]	Barbieri A, Giuliani E, Carone C, et al. Clinical severity of ischemic stroke and neural damage biomarkers in the acute setting: the stroke markers (STROMA) study[J]. Minerva Anestesiol, 2013, 79(7): 750-757. http://www.ncbi.nlm.nih.gov/pubmed/23511364
[19]	孟清, 陈芹芹, 杨丽君, 等. 幽门螺杆菌感染与2型糖尿病的相关性分析[J]. 世界最新医学信息文摘, 2018, 18(18): 32-33, 39. https://www.cnki.com.cn/Article/CJFDTOTAL-YXXS200820084.htm
[20]	Chongruksut W, Limpakan Yamada S, Chakrabandhu B, et al. Correlation of Helicobacter pylori and interleukin-8 mRNA expression in high risk gastric cancer population prediction[J]. World J Gastrointest Oncol, 2016, 8(2): 215-221. doi: 10.4251/wjgo.v8.i2.215
[21]	朱春英. 幽门螺杆菌感染与糖尿病的相关性[J]. 河北医药, 2017, 39(3): 445-446. https://www.cnki.com.cn/Article/CJFDTOTAL-LCXH202006024.htm
[22]	韩煦. 中老年人群2型糖尿病危险因素识别和发生风险预测模型建立[D]. 武汉: 华中科技大学, 2017.
[23]	Park M J, Choi S H, Kim D, et al. Association between helicobacter pylori seropositivity and the coronary artery calcium score in a screening population[J]. Gut Liver, 2011, 5(3): 321-327. doi: 10.5009/gnl.2011.5.3.321
[24]	Gunji T, Matsuhashi N, Sato H, et al. Helicobacter pylori infection is significantly associated with metabolic syndrome in the Japanese population[J]. Am J Gastroenterol, 2008, 103(12): 3005-3010. doi: 10.1111/j.1572-0241.2008.02151.x
[25]	王少君, 邹德玲, 任丽, 等. 幽门螺杆菌感染对老年急性冠状动脉综合征患者炎性因子、血脂指标和冠状动脉狭窄程度的影响[J]. 疑难病杂志, 2018, 17(10): 1099-1103. doi: 10.3969/j.issn.1671-6450.2018.10.005
[26]	Hosseini A, Salman M, Zhou Z, et al. Level of dietary energy and 2, 4-thiazolidinedione alter molecular and systemic biomarkers of inflammation and liver function in Holstein cows[J]. J Anim Sci Biotechnol, 2017, 8: 64-64. doi: 10.1186/s40104-017-0196-y
[27]	Vanessa K. Ridaura, Jeremiah J. Faith, Federico E. Rey, Jiye Cheng, Alexis E. Duncan. Cultured gut microbiota from twins discordant for obesity modulate adiposity and metabolic phenotypes in mice[J]. Science, 2013, 341(6150): 1241214-1241214. doi: 10.1126/science.1241214
[28]	练卫星, 张义军, 刘忆玲. 门诊受检患者幽门螺杆菌检测中¹³C-尿素呼气试验的应用价值分析[J]. 临床检验杂志: 电子版, 2019, 8(3): 6-6. https://www.cnki.com.cn/Article/CJFDTOTAL-LNJI201903004.htm
[29]	李勋, 蔡英茂, 金仁仙, 等. Kawamura分类法在评价幽门螺杆菌感染和胃炎中的价值[J]. 临床内科杂志, 2019(4): 247-249. doi: 10.3969/j.issn.1001-9057.2019.04.009
[30]	杨林, 康乐斯基, 江华, 等. 阿坝州藏区人群幽门螺杆菌感染流行病学调查及相关影响因素分析[J]. 实用医院临床杂志, 2019, 16(2): 18-20. doi: 10.3969/j.issn.1672-6170.2019.02.006
[31]	张琰, 程艳萍, 杨圣, 等. 南京市鼓楼区中老年居民幽门螺杆菌感染现状及相关因素研究[J]. 中国预防医学杂志, 2019, 20(1): 1-5. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYC201901003.htm

施引文献(10)

期刊类型引用(5)

1.	谢伟贤，唐琼林，王泳仪，林宗航，陆文敏，李恒. Narcotrend脑电监测在妇科腹腔镜手术静吸复合麻醉中的应用研究. 中国医学创新. 2022(02): 171-176 . 百度学术
2.	王莹，周蔚蓝，冯定祥. 不同浓度七氟烷瑞芬太尼静吸复合麻醉在消化道肿瘤根治术中应用及对术中血流动力学、术后麻醉恢复的影响. 世界华人消化杂志. 2022(23): 1039-1045 . 百度学术
3.	陈丽，罗涛，吕东森，王珊，温涛，刘华，袁承城，肖腾. 等效镇痛剂量舒芬太尼、瑞芬太尼对Narcotrend指数、血流动力学及抑制气管插管反应的效价比较. 现代中西医结合杂志. 2021(26): 2942-2945+2949 . 百度学术
4.	黄梅. Narcotrend脑电意识深度监测在小儿日间手术全身麻醉中的应用. 中国医药科学. 2020(01): 227-229+242 . 百度学术
5.	谭周鹏. 不同浓度瑞芬太尼辅助麻醉对肺癌根治术患者围术期免疫功能的影响. 临床研究. 2020(07): 36-38 . 百度学术