Application of ketogenic diet in cancer treatment
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摘要: 生酮饮食因极低碳水化合物、适量蛋白质和足量脂肪的摄入而导致机体血糖水平下降，胰岛素分泌减少和胰岛素样生长因子-1(IGF-1)轴活性的下降，对于有氧糖酵解极度活化的恶性肿瘤细胞有一定的抑制作用。本文从安全性，对神经系统肿瘤、前列腺癌、乳腺癌等多种肿瘤的有效性，以及与放疗、维生素D的协同作用等方面做较全面的阐述。Abstract: Ketogenic diet is a specific diet with very low carbohydrates, moderate to low protein and sufficient fat, which causes decreasing of blood glucose, insulin secretion, activity of insulin-like growth factor-1 (IGF-1) axis, and inhibiting in proliferation of cancer cells with hyperactivity of aerobic glycolysis. This paper reviewed on the safety of ketogenic diets and efficacy of nervous system tumors, prostate cancer, breast cancer and other tumors, as well as its synergistic effect with radiotherapy and vitamin D.
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Keywords:
- ketogenic diet /
- nervous system tumors /
- breast cancer /
- prostate cancer /
- cancer cachexia /
- low carbohydrates /
- insulin /
- vitamin D
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表 1 正在开展和已经完成的生酮饮食干预恶性肿瘤的临床研究
临床试验注册号 研究主题 研究机构 神经系统肿瘤 NCT03278249 Feasibility Study of Modified Atkins Ketogenic Diet in the Treatment of Newly Diagnosed Malignant Glioma University of Cincinnati NCT03075514 Ketogenic Diets as an Adjuvant Therapy in Glioblastoma University of Liverpool NCT02286167 Glioma Modified Atkins-based Diet in Patients With Glioblastoma Wake Forest University Health Sciences NCT02046187 Ketogenic Diet With Radiation and Chemotherapy for Newly Diagnosed Glioblastoma St.Joseph′s Hospital and Medical Center NCT01754350 Calorie-restricted Ketogenic Diet and Transient Fasting During Reirradiation for Patients With Recurrent Glioblastoma Johann Wolfgang Goethe University Hospital NCT01535911 Pilot Study of a Metabolic Nutritional Therapy for the Management of Primary Brain Tumors Michigan State University|Sparrow Health System NCT00575146 Ketogenic Diet for Recurrent Glioblastoma University Hospital Tuebingen 乳腺癌 NCT02092753 Ketogenic or LOGI Diet In a Breast Cancer Rehabilitation Intervention (KOLIBRI) Universitätsmedizin Mannheim NCT02744079 Comparison of Healthy Diets on Breast Cancer Markers Albert Einstein College of Medicine NCT03962647 A 2-Week Ketogenic Diet in Combination With Letrozole to Modulate PI3K Signaling in ER+Breast Cancer Vanderbilt-Ingram Cancer Center NCT03535701 Ketogenic Diet and Chemotherapy in Affecting Recurrence in Patients With Stage IV Breast Cancer Ohio State University Comprehensive Cancer Center 胰腺癌 NCT03510429 Clinical Validation of Nutritional Supplements(“Ketogenic Plus”) Developed for Pancreaticobiliary Cancer Patients Yonsei University NCT02964806 Development and Clinical Validation of Ketogen-based Therapeutic Diet for Pancreaticobiliary Cancer Patients Yonsei University NCT01419483 Ketogenic Diet With Concurrent Chemoradiation for Pancreatic Cancer University of Iowa 前列腺癌 NCT03679260 Carbohydrate Restricted Diet Intervention for Men on Prostate Cancer Active Surveillance Cedars-Sinai Medical Center NCT03194516 Ketogenic Diet and Prostate Cancer Surveillance Pilot University of Maryland 肺癌 NCT01419587 Ketogenic Diet With Chemoradiation for Lung Cancer (KETOLUNG) University of Iowa 黑色素瘤 NCT03950635 Dietary Intervention in Patients With a History of Melanoma M.D.Anderson Cancer Center 头颈部肿瘤 NCT01975766 Ketogenic Diet Phase 1 for Head & Neck Cancer University of Iowa 卵巢癌 NCT03285152 A Study of Ketogenic Diet in Newly Diagnosed Overweight or Obese Endometrial Cancer Patients Memorial Sloan Kettering Cancer Center 其他 NCT02516501 Impact of a Ketogenic Diet Intervention During Radiotherapy on Body Composition MVZ Leopoldina GmbH|dr.reinwald healthcare NCT01716468 Ketogenic Diet in Advanced Cancer VA Pittsburgh Healthcare System NCT01092247 The Effect of Ketogenic Diet on Malignant Tumors-Recurrence and Progress Tel-Aviv Sourasky Medical Center 
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