Objective  To explore the effect of nursing case management on early clinical efficacy for acute stroke patients with thrombolytic therapy.

  Methods  A total of 80 patients with acute ischemic stroke who received thrombolytic therapy were randomly divided into two groups. Control group received routine nursing and experimental group received case management nursing. The time from admission to thrombolytic therapy was recorded. National Institutes of Health Stroke Scale (NIHSS) scores before and after 24 h of thrombolytic therapy in two groups were compared.

  Results  The time from admission to thrombolysis was (34.22±4.83) min in the experimental group, which was significantly less than (70.56±7.68) min in the control group(P < 0.05). There was no significant difference in NIHSS score between the two groups before thrombolytic therapy(P > 0.05). At 24 h after treatment, the NIHSS score in the experimental group was significantly lower than treatment before and the control group (P < 0.05), but the control group showed no significant improvement compared to treatment before (P > 0.05).

  Conclusion  Nursing case management is helpful for improving the early clinical effect of thrombolytic therapy in patients with acute ischemic stroke.