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布比卡因联合芬太尼蛛网膜下腔麻醉在老年手术中的应用效果

Application of subarachnoid anesthesia by bupivacaine combined with fentanyl in elderly patients with operation

    摘要
  • 摘要:
      目的  探讨布比卡因联合芬太尼蛛网膜下腔麻醉在老年手术中的应用效果。
      方法  将本院收治行手术治疗的老年患者156例随机分成2组, 各78例。对照组采用布比卡因行蛛网膜下腔麻醉，研究组采用布比卡因联合芬太尼行蛛网膜下腔麻醉，比较2组患者麻醉效果及各临床指标的变化情况。
      结果  研究组麻醉阻滞时间、完善时间均长于对照组(P < 0.05), 研究组局麻药用量少于对照组(P < 0.05); 麻醉后，研究组血管性血友病因子(vWF)、纤维蛋白原(FIB)、凝血酶抗凝血酶复合物(TAT)、D-二聚体水平显著低于对照组(P < 0.05); 麻醉后，研究组收缩压、舒张压以及心率均高于对照组(P < 0.05); 研究组运动阻滞起效时间以及恢复时间、镇痛起效时间、痛觉恢复时间均短于对照组(P < 0.05)。
      结论  布比卡因联合芬太尼对老年手术患者行蛛网膜下腔麻醉的应用效果显著。

     

    Abstract:
      Objective  To investigate the application of subarachnoid anesthesia by bupivacaine combined with fentanyl in elderly patients with operation.
      Methods  A total of 156 elderly patients underwent surgery in our hospital were randomly divided into two groups, with 78 cases in each group. The control group was given bupivacaine for subarachnoid anesthesia, while the study group was treated with bupivacaine and fentanyl in combination for subarachnoid anesthesia. The anesthetic effects and changes of clinical indicators were compared between the two groups.
      Results  The complete time for anesthesia and anesthesia blocking time in the study group were significantly longer than those in the control group (P < 0.05), while the amount of local anesthesia was significantly less than that in the control group (P < 0.05). After the anesthesia, the levels of von Willebrand factor (vWF), fibrinogen (FIB), thrombin antithrombin complex (TAT), D-dimer in the study group were lower than those in the control group (P < 0.05); the systolic blood pressure, diastolic blood pressure and heart rate of the study group were higher than those of the control group after anesthesia (P < 0.05); the onset time of exercise block and its recovery time, onset time of analgesia, and pain recovery time in the study group were shorter than those in the control group (P < 0.05).
      Conclusion  Bupivacaine combined with fentanyl has significant effects on subarachnoid anesthesia in elderly patients.

     

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