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呼出气一氧化氮测定在成人支气管哮喘治疗中的应用价值

Application value of exhaled nitric oxid detection in treatment of bronchial asthma in adults

    摘要
  • 摘要:
      目的  探讨呼出气一氧化氮(FeNO)测定在成人支气管哮喘治疗中的应用价值。
      方法  选取52例成人支气管哮喘患者为研究组, 另选取同期52名健康体检者为对照组。检测研究组治疗前(T0)及治疗1个月(T1)、3个月(T2)、6个月(T3)的FeNO、第1秒用力呼气量占预计值百分比(FEV1%), 同时检测对照组(不治疗)同时点的指标情况。分析研究组不同时点FEV1%与FeNO的相关性。
      结果  研究组T1、T2、T3时点FeNO显著低于T0时点，且研究组T1、T2时点FeNO显著高于对照组(P < 0.05)。研究组T1、T2、T3时点FEV1%显著高于T0时点，且研究组T1、T2时点FEV1%显著低于对照组(P < 0.05)。研究组T0时点FEV1%与FeNO呈显著负相关(P < 0.05)。
      结论  成人支气管哮喘治疗中, FeNO检测具有重要指导作用。

     

    Abstract:
      Objective  To explore the application value of exhaled nitric oxide (FeNO) in the treatment of bronchial asthmas in adults.
      Methods  A total of 52 adult patients with bronchial asthma were selected as study group, while 52 healthy subjects were selected as control group during the same period. FeNO and ratio of forced expiratory volume in first second (FEV1%) were detected in the study group at the time points of before treatment (T0), 1 month after treatment (T1), 3 months after treatment (T2), and 6 months after treatment (T3). At the same time, the indexes were also detected in the control group. The correlation between FEV1% and FeNO at different time points was analyzed in the study group.
      Results  FeNO levels at T1, T2 and T3 in the study group were significantly lower than that at T0, and FeNO levels at T1 and T2 in the study group were significantly higher than those in the control group (P < 0.05). The values of FEV1% at T1, T2 and T3 in the study group were significantly higher than that at T0, and the values of FEV1% at T1 and T2 in the study group were significantly lower than those in the control group (P < 0.05). FEV1% value at T0 was negatively correlated with FeNO level in the study group (P < 0.05).
      Conclusion  FeNO detection plays an important guiding role in the treatment of bronchial asthma in adults.

     

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