Objective  To investigate the efficacy of duloxetine combined with eperisone in tension headache patients with anxiety disorder.

  Methods  Fifty tension headache patients with anxiety disorder who were treated in outpatient clinic were selected as subjects, and were randomly divided into experimental group and control group, with 25 cases in each group. The patients in the experimental group were treated with eperisone hydrochloride tablets combined with duloxetine enteric-coated capsules, and the control group was only treated with eperisone hydrochloride tablets. All patients were observed for 4 weeks. The side effects were assessed by the Side Effects Scale (TESS). The Visual Analogue Scale (VAS) was used to evaluate the degree of headache at the beginning and end of the study, and the anxiety was assessed using the Hamilton Anxiety Scale (HAMA).

  Results  After treatment, the VAS scores and HAMA scores of the two groups were significantly lower than treatment before (P < 0.05), and the indicators in the experimental group were significantly lower than that of the control group (P < 0.05). There was no significant difference in the incidence of side reactions between the two groups (P>0.05).

  Conclusion  Duloxetine combined with eperisone can effectively and safely relieve the symptoms of patients with tension headache and anxiety disorders.