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上皮细胞黏附因子及肿瘤相关糖蛋白-72在结肠癌中的表达及临床意义

Expression and clinical significance of epithelial cell adhesion factor and tumor associated glycoprotein-72 in colon cancer

    摘要
  • 摘要:
      目的  探讨上皮细胞黏附因子(EpCAM)、肿瘤相关糖蛋白-72(TAG-72)在结肠癌组织中的表达及临床意义。
      方法  采用免疫组化法检测132例结肠癌组织中EpCAM、TAG-72表达并计算评分，分析EpCAM、TAG-72表达与临床病理特征、预后的关系。
      结果  EpCAM表达阳性率为65.91%, 平均评分(2.48±0.54)分; TAG-72表达阳性率为70.45%, 平均评分(2.56±0.62)分; EpCAM阳性并TAG-72表达阳性率为58.33%, 平均评分(3.12±0.60)分。肿瘤直径>3 cm、低分化/黏胰腺、TNM分期(Ⅲ、Ⅳ期)、T3~4浸润深度、有淋巴结转移的结肠癌患者EpCAM表达阳性率及TAG-72表达阳性率、评分显著高于肿瘤直径≤3 cm、高中分化、TNM分期(Ⅰ、Ⅱ期)、T1~2浸润深度、无淋巴结转移者(P < 0.05或P < 0.01)。EpCAM表达阳性、TAG-72表达阳性、EpCAM表达并TAG-72表达阳性者评分显著高于表达阴性者，生存时间显著短于表达阴性者(P < 0.01); EpCAM表达阳性并TAG-72表达阳性者评分显著高于EpCAM表达阳性者、TAG-72表达阳性者(P < 0.01), 生存时间显著短于EpCAM表达阳性者、TAG-72表达阳性者(P < 0.01)。
      结论  EpCAM、TAG-72表达与结肠癌肿瘤直径、分化程度、TNM分期、浸润深度、淋巴结转移相关, EpCAM、TAG-72阳性表达者生存时间明显缩短, EpCAM与TAG-72均阳性表达者预后更差。

     

    Abstract:
      Objective  To investigate the expression and clinical significance of epithelial cell adhesion factor (EpCAM) and tumor associated glycoprotein-72 (TAG-72) in colon cancer.
      Methods  Expressions of EpCAM and TAG-72 in 132 cases of colon cancer was detected by immunohistochemistry, and the scores were calculated. The relationship between the expression of EpCAM, TAG-72 and the clinicopathological characteristics, prognosis was analyzed.
      Results  The positive rate of EpCAM was 65.91%, with an average score of (2.48±0.54) points. The positive rate of TAG-72 was 70.45%, with an average score of (2.56±0.62) points. The positive rate of EpCAM and TAG-72 was 58.33%, with an average score of (3.12±0.60) points. The positive rates of EpCAM, TAG-72 and scores were significantly higher in patients with pathological characteristics such as tumor diameter over 3 cm, low differentiation/mucociliary pancreas, TNM stage (stage Ⅲ to Ⅳ), T3~4 depth of invasion and lymph node metastasis than those with tumor diameter less or equal to 3 cm, high differentiation, TNM stage (stage Ⅰ to Ⅱ), T1~2 depth of invasion and no lymph node metastasis (P < 0.05 or P < 0.01). The scores of patients with positive EpCAM, positive TAG-72, positive EpCAM and positive TAG-72 expressions were significantly higher than those with negative expressions, and the survival time was significantly shorter than those with negative expressions (P < 0.01). The scores of patients with positive EpCAM and positive TAG-72 expression were significantly higher than those with only positive EpCAM or positive TAG-72 expressions (P < 0.01), and the survival time was significantly shorter than those with only positive EpCAM or positive TAG-72 expressions (P < 0.01).
      Conclusion  The expressions of EpCAM and TAG-72 are related to tumor diameter, differentiation degree, TNM stage, invasion depth and lymph node metastasis. The survival time of patients with positive EpCAM, TAG-72 expressions shorter significantly, and the prognosis of patients with positive expressions of both EpCAM and TAG-72 is worse.

     

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