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变应原疫苗免疫治疗对过敏性支气管哮喘合并鼻炎患者的效果

Effect of immunotherapy with allergen vaccine in allergicbronchial asthma patients combined with rhinitis

    摘要
  • 摘要:
      目的  探讨变应原疫苗免疫治疗对过敏性支气管哮喘合并鼻炎患者的临床效果。
      方法  选取100例过敏性支气管哮喘合并鼻炎患者进行研究，将其随机均分为2组，对照组采用舒利迭联合布地奈德鼻喷剂治疗，观察组采用变应原疫苗免疫治疗，对2组的治疗效果进行比较。
      结果  观察组患者的治疗总有效率显著高于对照组(P < 0.05); 治疗后，观察组哮喘控制测试(ACT)评分显著高于对照组，过敏性鼻炎症状评分显著低于对照组(P < 0.05); 治疗后，观察组的生存质量总评分显著高于对照组(P < 0.05); 2组不良反应发生率无显著差异(P>0.05)。
      结论  过敏性支气管哮喘合并鼻炎患者采用变应原疫苗免疫治疗效果理想，可促进患者哮喘及鼻炎症状改善，提升患者生存质量，安全性较高。

     

    Abstract:
      Objective  To investigate the effect of immunotherapy with allergen vaccine in allergic bronchial asthma patients combined with rhinitis.
      Methods  A total of 100 patients with allergic bronchial asthma combined with rhinitis in our hospital were randomly divided into two groups. The control group(n=50) was treated with seretide combined with budesonide nasal spray, while the observation group(n=50) used immunotherapy with allergen vaccine, the therapeutic effects of the two groups were compared.
      Results  The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, the asthma control test (ACT) score in the observation group was significantly higher, and the allergic rhinitis symptom scores was significantly lower than that of the control group(P < 0.05). After treatment, the total quality of life in the observation group was significantly higher than that in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).
      Conclusion  Allergen vaccine can improve the symptoms of asthma and rhinitis, and improve the quality of life of patients with allergic bronchial asthma complicated with rhinitis. Meanwhile, it has an ideal therapeutic efficacy and higher safety.

     

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