Objective  To explore the role of nursing strategy of daily replacement of medical fabric in the prevention and control of nosocomial infection in patients with infection or colonization of multi-drug resistant bacteria.

  Methods  In the comprehensive ICU, the patients with multiple drug-resistant bacteria colonization or infection were detected by active screening, and the medical fabrics in direct contact with the skin were replaced every day, and the fabrics polluted by blood, body fluid and excreta were replaced immediately.

  Results  From January to June 2017, 428 patients were monitored and designed as pre-intervention group. From July to December 2017, 507 patients were monitored and designed as post-intervention group. In the post-intervention group, the hospital infection rate of multi-drug resistant bacteria in one thousand days, case rate of hospital infection with multi-drug resistance bacteria, incidence of nosocomial infection, case rate of nosocomial infection, incidence of nosocomial infection in one thousand days, case rate of nosocomial infection in one thousand days and colony count of medical fabric were better than those in pre-intervention group.

  Conclusion  In the comprehensive ICU, the nursing strategy of daily replacement of medical fabric in the patients with multi-drug resistant bacteria infection or colonization has a better effect in the prevention and control of nosocomial infection.