Clinical effect of Wutou Decoction on polymyalgia rheymatica
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摘要:目的 探讨乌头汤治疗风湿性多肌痛(PMR)的临床疗效。方法 选择PMR患者160例分为观察组与对照组，各80例。对照组给予强的松治疗，观察组在对照组治疗基础上加用乌头汤治疗，比较2组患者治疗效果、C反应蛋白(CRP)、血沉(ESR)、血红蛋白(HGB)、血小板(PLT)水平变化。同时，观察晨僵消失时间、ESR恢复至0~20 mm/h的时间、CRP恢复正常值时间。结果 观察组患者治疗有效率高于对照组，差异有统计学意义(P < 0.05); 2组治疗后CRP、ESR、PLT水平均低于治疗前(P < 0.05); 治疗后, 2组HGB高于治疗前，差异有统计学意义(P < 0.05); 治疗后，观察组CRP、ESR、PLT水平显著低于对照组，HGB水平显著高于对照组，差异有统计学意义(P < 0.05); 观察组患者晨僵消失时间、ESR恢复至0~20 mm/h时间、CRP恢复正常值时间短于对照组，差异有统计学意义(P < 0.05)。结论 乌头汤联合强的松治疗PMR具有显著疗效，可有效改善患者临床症状。Abstract:Objective To discuss the effect of Wutou Decoction on polymyalgia rheymatica.Methods A total of 160 patients with polymyalgia rheymatica were divided into observation group(n=80) and control group(n=80), the controlgroup was treated with prednisone, the observation group was treated with Wutou Decoction on the basis of the control group. The therapeutic effects, changes of C reactive protein (CRP), erythrocyte sedimentation rate(ESR), hemoglobin(HGB) and blood platelet(PLT) levels were compared. The disappearance time of stiffness in the morning, recovery time of ESR to 0~20 mm/h and recovery time of CRP to normal value were compared between the two groups.Results The effective rate of treatment in the observation group was significantly higher than the control group (P < 0.05); the CRP, ESR and PLT levels in the two groups after treatment were significantly lower, and HGB level was significantly higher than treatment before(P < 0.05). After treatment, the levels of CRP, ESR and PLT in the observation group were significantly lower, and HGB levels were significantly higher than those in the control group (P < 0.05); the observation group had lower disappearance time of stiffness in the morning, recovery time of ESR to 0~20 mm/h and recovery time of CRP to normal value than that in the control group (P < 0.05).Conclusion ERCP combined with EST has higher efficacy in the treatment of patients with PMR, and improve the clinical efficacy.
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Keywords:
- Wutou Decoction /
- prednisone /
- rheumatic myalgia /
- stiffness in the morning
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表 1 2组患者治疗效果比较[n(%)]
组别 n 显效 有效 无效 总有效 观察组 80 66(82.5) 12(15.0) 2(2.5) 78(97.5) 对照组 80 30(37.5) 20(25.5) 30(37.5) 50(62.5)* 与观察组比较, *P＜0.05。 
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表 2 2组患者治疗前后CRP、ESR、PLT、HGB水平比较(x±s)
组别 时间 CRP/(mg/L) ESR/(mm/h) HGB/(g/L) PLT/(×109/L) 观察组(n=80) 治疗前 23.1±22.0 57.1±7.0 100.2±2.0 412.5±20.1 治疗后 9.1±4.1*# 23.2±4.0*# 129.1±2.1*# 249.2±10.9*# 对照组(n=80) 治疗前 22.1±2.5 53.1±7.2 99.9±2.1 416.2±20.7 治疗后 18.5±2.1* 36.2±4.1* 118.2±1.7* 304.4±21.2* CRP: C反应蛋白; ESR: 红细胞沉降率; HGB: 血红蛋白; PLT: 血小板。与治疗前比较, *P＜0.05; 与对照组比较, #P＜0.05。
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表 3 2组PMR患者治疗后各指标恢复正常时间比较(x±s)
d 组别 n 晨僵消失时间 ESR恢复至正常时间 CRP恢复正常值时间 观察组 80 4.0±0.4* 18.1±1.6* 6.1±1.3* 对照组 80 6.0±0.6 39.4±2.9 9.8±1.2 与对照组比较, *P＜0.05。
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[1] 赵梅花, 张晗, 胡逢来, 等. 风湿性多肌痛二例并文献复习[J]. 海南医学, 2019, 30(7): 892-895. doi: 10.3969/j.issn.1003-6350.2019.07.023 [2] 张金晓. 乌头汤联合强的松治疗风湿性多肌痛的临床疗效分析[J]. 临床医学, 2015, 35(10): 125-126. https://www.cnki.com.cn/Article/CJFDTOTAL-EBED201510069.htm [3] McCarthy E M, MacMullan P A, Al-Mudhaffer S, et al. Plasma fibrinogen is an accurate marker of disease activity in patients with polymyalgia rheumatica[J]. Rheumatology, 2013, 52(3): 465-471. doi: 10.1093/rheumatology/kes294
[4] 廖秋菊, 赵义, 黄旭, 等. 老年风湿性多肌痛患者血清纤维蛋白原水平变化及意义[J]. 中华实用诊断与治疗杂志, 2016, 30(11): 1087-1088. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD201611017.htm [5] 高利霞. 抗CCP抗体、抗RA33抗体及RF联合检测对类风湿关节炎的临床诊断价值[J]. 山西医科大学学报, 2014, 45(2): 116-118. doi: 10.3969/J.ISSN.1007-6611.2014.02.010 [6] Liu S, Liu J, Wang X D. Caregiver burden, sleep quality, depression, and anxiety in dementia caregivers: a comparison of frontotemporal lobar degeneration, dementia with Lewy bodies, and Alzheimers disease[J]. Int Psychogeriatr, 2017, 10: 1-8. http://www.ncbi.nlm.nih.gov/pubmed/29223171
[7] Dejaco C, Singh Y P, Perel P, et al. 2015 Recommendations for the management of polymyalgia rheumatia: a European League Against Rheumatism/American College of Rheumatology collaborative initiative[J]. Ann Rheun Dis, 2015, 74(10): 1799-1807. doi: 10.1136/annrheumdis-2015-207492
[8] Macchioni P, Boiardi L, Catanoso M, et al. Performance of the new 2012 EULAR/ACR classification criteria for polymyalgia rheumatica: comparison with the previous criteria in a single-centre study[J]. Ann Rheum Dis, 2014, 73(6): 1190-1193. doi: 10.1136/annrheumdis-2013-204167
[9] Mollayeva T, Thurairajah P, Burton K, et al. The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples: A systematic review and meta-analysis[J]. Sleep Med Rev, 2016, 25: 52-73. doi: 10.1016/j.smrv.2015.01.009
[10] 王付. 乌头汤与半夏泻心汤合方辨治关节疼痛[J]. 中医杂志, 2016, 57(6): 524-526. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYZ201606020.htm [11] 王涛, 林静, 狄舒男, 等. 乌头汤及其拆方对116例寒湿型类风湿性关节炎临床疗效观察[J]. 时珍国医国药, 2016, 27(1): 145-146. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY201601055.htm [12] 崔亮界. 加味乌头汤配合牵引治疗神经根型颈椎病82例[J]. 陕西中医, 2011, 32(8): 994-995. doi: 10.3969/j.issn.1000-7369.2011.08.036 -
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