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白蛋白联合血浆输注对肾综合征出血热休克患者休克持续时间及肾功能的影响

Effect of albumin combined with plasma transfusionon duration of shock and renal function in patients with hemorrhagic fever shock with renal syndrome

    摘要
  • 摘要:
      目的  探讨白蛋白联合血浆输注对肾综合征出血热休克患者休克持续时间及肾功能的影响。
      方法  按照随机数字表法将本院肾综合征出血热休克患者100例分为2组，每组各50例。对照组采用常规治疗，观察组采用白蛋白联合血浆输注治疗，比较2组患者休克持续时间、肾功能情况、炎性因子水平、并发症发生率。
      结果  观察组休克持续时间短于对照组，差异有统计学意义(P < 0.01); 治疗后，观察组尿素氮(BUN)、血肌酐(SCr)水平低于对照组，差异有统计学意义(P < 0.05); 治疗后，观察组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平低于对照组，差异有统计学意义(P < 0.05); 观察组渗出性肺炎、继发菌血症、多器官出血发生率低于对照组，差异有统计学意义(P < 0.05)。
      结论  白蛋白联合血浆输注治疗可缩短肾综合征出血热休克患者的休克持续时间，提高肾功能，减轻炎症反应，减少并发症。

     

    Abstract:
      Objective  To investigate the effect of albumin combined with plasma transfusion on duration of shock and renal function in patients with hemorrhagic fever shock with renal syndrome.
      Methods  A total of 100 patients with hemorrhagic fever shock with renal syndrome in the hospital were divided into two groups by random number table method, with 50 cases in each group. Control group was given routine treatment, and observation group was treated with albumin combined with plasma transfusion. The duration of shock, renal function, inflammatory factors, incidences of complications were compared between two groups.
      Results  The duration of shock in observation group was shorter than that in control group, and the difference was statistically significant (P < 0.01); after treatment, the levels of blood urea nitrogen (BUN) and serum creatinine (Scr) in observation group were lower than those in control group (P < 0.05); after treatment, the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in observation group were lower than those in control group (P < 0.05); the incidences of exudative pneumonia, secondary bacteremia, multiple organ hemorrhage in observation group were lower than that in control group (P < 0.05).
      Conclusion  Albumin combined with plasma transfusion for patients with hemorrhagic fever shock with renal syndrome can shorten duration of shock, improve renal function, relieve inflammatory response, and reduce complications.

     

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