妊娠肝内胆汁淤积症产妇血清总胆汁酸、甘胆酸水平检测及新生儿肺损伤状况分析

田小飞; 马欢

doi:10.7619/jcmp.201922029

妊娠肝内胆汁淤积症产妇血清总胆汁酸、甘胆酸水平检测及新生儿肺损伤状况分析

田小飞¹,
马欢^2, ,

1.
陕西省榆林市第一医院儿内科, 陕西榆林, 719000
2.
陕西省榆林市第一医院妇产科, 陕西榆林, 719000

详细信息

通讯作者:
马欢, E-mail: 958414331@qq.com

中图分类号: R563
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出版历程
- 收稿日期: 2019-09-09
- 录用日期: 2019-10-24
- 网络出版日期: 2021-02-28
- 发布日期: 2019-11-27

Detection of serum total bile acid and cholyglycinelevels in women with intrahepatic cholestasis ofpregnancy and analysis of neonatal lung injury

TIAN Xiaofei¹,
MA Huan^2, ,

1.
Department of Pediatrics, The First Hospital of Yulin in Shaanxi Province, Yulin, Shaanxi, 719000
2.
Department of Obstetrics and Gynecology, The First Hospital of Yulin in Shaanxi Province, Yulin, Shaanxi, 719000

摘要

摘要:
目的探讨妊娠肝内胆汁淤积症(ICP)产妇血清总胆汁酸(TBA)、甘胆酸(CG)水平及新生儿肺损伤状况。
方法选择60例ICP产妇设为观察组, 并选择同期60例健康产妇设为对照组。比较2组产妇的血清TBA、CG水平，并比较2组新生儿肺动脉血流指数、肺损伤情况。
结果观察组产妇血清TBA、CG水平高于对照组产妇，差异有统计学意义(P＜0.01); 观察组新生儿的肺损伤发生率、肺动脉血流指数高于对照组，差异有统计学意义(P＜0.05); 观察组出现新生儿肺炎、呼吸窘迫、窒息对应的产妇血清TBA水平分别为(22.67±4.57)、(32.23±7.78)、(65.83±14.57)μmol/L, 血清TBA水平与新生儿肺损伤程度呈显著正相关(r=0.653, P＜0.01)。
结论 ICP产妇的血清TBC、CG水平显著高于健康产妇，且ICP产妇血清TBA、CG水平的升高与新生儿肺损伤的发生有一定相关性。
- 妊娠肝内胆汁淤积症 /
- 孕妇 /
- 总胆汁酸 /
- 甘胆酸 /
- 新生儿肺损伤
Abstract:
Objective To analyze the levels of serum total bile acid (TBA), cholyglycine (CG) of pregnant women with intrahepatic cholestasis of pregnancy (ICP) and conditions of neonatal lung injury.
Methods A total of 60 ICP puerperas were selected as observation group, and 60 healthy puerperas during the same period were selected as control group. Serum TBA, CG levels were compared, and neonatal pulmonary artery blood flow index as well as lung injury of the two groups were compared.
Results The serum levels of TBA and CG in the observation group were significantly higher than those in the control group (P < 0.01). The incidence of neonatal lung injury, pulmonary artery blood flow index in the observation group were significantly higher than that in the control group (P < 0.05). The serum TBA levels of puerperas with delivered neonates complicating neonatal pneumonia, respiratory distress and asphyxia in the observation group were (22.67±4.57), (32.23±7.78), (65.83±14.57) μmol/L, respectively, which showed positive correlations with the degree of neonatal lung injury (r=0.653, P < 0.01).
Conclusion The serum TBA and CG levels of pregnant ICP women are significantly higher than those of normal healthy women, and their higher levels are correlated with the occurrence of neonatal lung injury.
- pregnancy cholestasis /
- pregnant women /
- total bile acid /
- glycocholic acid /
- neonatal lung injury

HTML全文

表 1 2组产妇血清TBA、CG水平比较(x±s)

组别	n	TBA/(μmol/L)	CG/(μg/mL)
对照组	60	2.67±1.56	1.43±0.61
观察组	60	33.43±3.72^**	48.32±5.21^**
TBA: 总胆汁酸; CG: 甘胆酸。与对照组比较, **P＜0.01。

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表 2 2组新生儿肺损伤发生情况比较[n(%)]

组别	n	呼吸窘迫	新生儿肺炎	窒息	合计
对照组	60	9(15.00)	5(8.33)	0	14(23.33)
观察组	60	21(35.00)	7(11.66)	4(6.66)	32(53.33)^*
与对照组比较, *P＜0.05。

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表 3 2组新生儿肺动脉血流指数比较(x±s)

组别	n	肺主动脉血流指数
组别	n	S/D	RI	PI
对照组	60	5.46±0.58	2.03±0.15	0.80±0.05
观察组	60	6.69±0.72^*	2.22±0.17^*	0.90±0.07^*
S/D: 收缩期最大血流速度与舒张末期血流速度比值; RI: 阻力指数; PI: 脉搏指数。与对照组比较, *P＜0.05。

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