Abstract: Nowadays, the biomedicine researches are highly benefited by the development and improvement of biotechnology, and these technologies produced huge amounts of biological data. It becomes very important to find better approaches to integrate and apply these complex biological data to support and drive the biomedical studies. Computational biology was emerged for this purpose, by covering and fusing multiple domains of sciences, including computer science, biological science, medicine, chemistry, pharmacy, mathematics, and statistics. This commentary article will briefly introduce the field of computational biology, elaborate why it is highly demanded, and discuss its current situations and opportunities.