Effect of artificial tears in prevention of topical ocular injury caused by topical anti glaucoma drugs
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摘要: 目的 探讨人工泪液在预防局部应用抗青光眼药物造成眼表损伤中的作用。 方法 选取局部应用抗青光眼药物治疗的原发性开角型青光眼患者96例,随机分为观察组和对照组,每组48例。对照组仅应用抗青光眼药物治疗,观察组则应用抗青光眼药物治疗联合人工泪液治疗,治疗3个月后,观察所有患者的眼压、泪膜破裂时间,并对患者行SchirmerⅠ试验(SIt)及角膜荧光素钠染色(FL)评分检查。 结果 治疗前, 2组眼压比较,差异无统计学意义(P>0.05); 治疗后, 2组眼压均较治疗前显著降低(P<0.05), 但2组间差异无统计学意义(P>0.05)。治疗前, 2组泪膜破裂时间比较,差异无统计学意义(P>0.05); 治疗后3个月,对照组泪膜破裂时间较治疗前缩短,且短于观察组,差异有统计学意义(P<0.05)。2组治疗前后SIt实验结果比较,差异无统计学意义(P>0.05); 治疗后,观察组FL评分优于对照组,差异有统计学意义(P<0.05)。 结论 人工泪液有利于维持眼展内膜的稳定性,对局部应用抗青光眼药物造成的眼表损伤有显著的预防效果。Abstract: Objective To analyze artificial tears in prevention of topical ocular injury caused by topical anti glaucoma drugs. Methods A total of 96 patients with primary open-angle glaucoma treated by anti glaucoma drugs were randomly divided into observation group and control group, with 48 cases in each group. The control group only used anti glaucoma drugs, while the observation group used anti glaucoma drug therapy combined with artificial tears treatment. After 3 months of treatment, the intraocular pressure, the breakup time of tear film, and underwent Schirmer I test(SIt)and corneal fluorescein staining(FL)score. Results No significant difference before treatment was seen in intraocular pressure(P>0.05). After treatment, intraocular pressure of the two groups was significantly decreased, but no difference between the two groups was found(P>0.05). Before treatment, there was no difference between tear break-up time(P>0.05). At 3 months after treatment, the control group the break-up time was significantly shortened, and was significantly shorter in the observation group compared to the control group(P<0.05). Before treatment, SIt showed no significant difference in two groups(P>0.05); after treatment, FL score of observation group was significantly better than that in the control group(P<0.05). Conclusion Artificial tears is favorable in maintaining the stability of ocular surface intima, and has better efficacy in prevention of topical ocular injury caused by topical anti glaucoma drugs.
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Keywords:
- artificial tears /
- anti glaucoma drugs /
- ocular surface injury /
- intraocular pressure
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