Abstract: Objective To investigate effects of nutritional support of multi-disciplinary diagnosis and treatment(MDT)mode in patients with pulmonary tuberculosis and diabetes. Methods A total of 52 patients with diabetes mellitus complicated with pulmonary tuberculosis who were hospitalized in our hospital were randomly divided into control group and intervention group. Intervention group was given treatments for pulmonary tuberculosis and diabetes as well as MDT personalized diet guidance. The control group was given regular diabetes diet based on treatments for pulmonary tuberculosis and diabetes. Biochemical indicators, absorption of lung lesions by chest CT examination, clearance rate of sputum bacteria and nutritional evaluation indicators of the two groups before and after treatment were observed and analyzed. Results After 1- and 6- month treatment, the blood biochemical parameters, absorption rate of lung lesion, clearance rate of sputum bacteria and nutritional evaluation index of the intervention group were better than those in the control group(P<0.05). Conclusion MDT nutritional support can improve the treatment effect, shorten the length of stay and reduce the medical cost.