Abstract: Objective To explore the effect of optimized clinical nursing path on the postoperative recovery efficiency and physiological stress of patients with ovarian cancer. Methods Totally 42 ovarian cancer patients admitted to our department from July to December 2018 were selected as control group, and were treated with routine nursing during the perioperative period. Another 43 ovarian cancer patients admitted to our department from January to June 2019 were selected as observation group, and were treated with clinical nursing pathway. The rehabilitation effect and physiological stress were compared between the two groups. Results The first time to exhaustion after operation, first time to defecation after operation, time of getting out of bed and postoper ative hospital stay in the observation group were significantly shorter than those in the control group(P<0.05). The incidence rate of postoperative complications in the observation group was lower than that in the control group, but no significant difference was found between two groups(P>0.05). The levels of cortisol(Cor), C reactive protein(CRP)and fasting blood glucose(Glu)in the observation group were significantly lower than those in the control group at 48 hours after operation(P<0.05). Conclusion Optimized clinical nursing pathway can reduce the physiological stress response of patients with ovarian cancer surgery, shorten the rehabilitation time and improve the rehabilitation efficiency.