Abstract: Objective To explore the effect of Compound Danshen Injection on blood lipid metabolism in patients with coronary heart disease and angina pectoris. Methods The clinical data of 170 patients with coronary heart disease and angina pectoris diagnosed and treated in the hospital were retrospectively analyzed, and they were divided into two groups according to different treatment plans: the patients who were treated with western medicine alone were selected as control group(n=85), and those treated with Compound Danshen Injection on the basis of western medicine were selected as study group(n=85). The total curative effect, symptoms of angina pectoris and the changes of blood lipid metabolism before and after treatment were analyzed. Results After treatment, the levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C)in the study group were lower and high density lipoprotein cholesterol(HDL-C)was higher than that in the control group, the duration of angina pectoris symptoms was shorter and the number of attacks was less than that in the control group, the overall effective rate of angina pectoris in the study group was higher than that in the control group(P<0.05). Conclusion Compound Danshen Injection has a positive effect on blood lipid metabolism in patients with angina pectoris, and can be used as an assistant treatment to improve the symptoms of angina pectoris.