Abstract: Objective To investigate the clinical effect of intravascular interventional therapy combined with recombinant tissue plasminogen activator(r-TPA)on arterial thrombolysis in patients with acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction treated in our hospital were selected and divided into control group(n=60)and observation group(n=60)according to the digital parity method, the former group used r-TPA arterial thrombolysis, while the latter group was combined with intravascular interventional therapy. Vascular recanalization rate, National Institutes of Health Stroke Scale(NIHSS)score and daily living ability between the two groups were compared. Results The complete recanalization rate of blood vessels in the observation group was higher, and the re-occlusion rate of the blood vessels was lower than that in the control group(P < 0.05). The NIHSS score was(3.24±0.61)points at 2 weeks after operation in the observation group, which was lower than(6.74±0.82)points of the control group; the daily living ability score was(89.35 ± 8.35)points at 4 weeks after operation in the observation group, which was higher than(75.26±8.14)points of the control group, the differences were statistically significant(P < 0.05). The incidence of bleeding events of the two groups showed no significant differences(P > 0.05). Conclusion Intravascular interventional therapy combined with recombinant tissue plasminogen activator can obtain ideal results, which can increase the recanalization rate and reduce the bleeding rate.