Clinical effect of bronchoscopy lavage combined with antibiotics in treatment of patients with refractory pulmonary multi-drug resistant bacteria infection
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摘要: 目的 探讨支气管镜灌洗联合抗生素治疗难治性肺部多重耐药菌感染的临床效果。 方法 选取150例难治性肺部多重耐药菌感染患者作为研究对象,将单纯采取抗生素治疗者设为对照组(n=75), 将采取支气管镜灌洗联合抗生素治疗者设为研究组(n=75), 比较2组患者的治疗效果、抗生素应用时间、住院时间、不良反应发生率以及细菌阴转率。 结果 研究组的治疗整体有效率(98.67%)高于对照组(88.00%), 差异有统计学意义(P < 0.05); 研究组抗生素使用时间、住院时间短于对照组,差异有统计学意义(P < 0.05); 研究组不良反应发生率(1.33%)低于对照组(10.67%), 差异有统计学意义(P < 0.05); 研究组细菌阴转率(97.33%)高于对照组(85.33%), 差异有统计学意义(P < 0.05)。 结论 支气管镜灌洗联合抗生素方案可作为难治性肺部多重耐药菌感染的首选疗法。
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关键词:
- 支气管镜灌洗 /
- 抗生素 /
- 难治性肺部多重耐药菌感染 /
- 不良反应 /
- 细菌阴转率
Abstract: Objective To investigate the clinical effect of bronchoscopy lavage combined with antibiotics in the treatment of patients with refractory pulmonary multidrug-resistant bacterial infection. Methods A total of 150 patients with refractory pulmonary multidrug-resistant bacterial infection were divided into control group(treated with antibiotics)and study group(treated with bronchoscopy lavage and antibiotic), with 75 cases in each group. The therapeutic effect, application time of antibiotics, hospitalization time, incidence of adverse reactions and bacterial negative conversion rate were compared between the two groups. Results The overall effective rate of treatment was 98.67% in the study group, which was significantly higher than 88.00% in the control group(P < 0.05). The application time of antibiotics and hospitalization time in the study group were significantly shorter than those in the control group(P < 0.05). The incidence rate of adverse reactions was 1.33% in the study group, which was significantly lower than 10.67% in the control group(P < 0.05). The bacterial negative conversion rate was 97.33 in the study group, which was significantly higher than 85.33% in the control group(P < 0.05). Conclusion Bronchoscope lavage combined with antibiotics can be used as the first choice for the treatment of patients with refractory pulmonary multidrug-resistant bacterial infection. -
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