Abstract: Objective To explore the clinical application of new non-invasive external fixation device in pre-hospital emergency treatment for pelvic fracture. Methods Sixty patients with pelvic fractures were selected and divided into control group and observation group according to the different fixation devices, with 30 cases in each group. After receiving basic treatment based on fracture condition, the control group was treated with conventional external fixation plate fixation or pelvic traction belt fixation, and the observation group was treated with a new non-invasive external fixation device. The pain relief after fixation, rebleeding rate, secondary injury rate and success rate of rescue were compared between the two groups. Results The scores of the simple McGill pain questionnaire(SF-MPQ)significantly reduced in both groups after fixation, and the scores of SF-MPQ after 15 and 30 minutes of fixation in the observation group were significantly lower than those in the control group(P < 0.05). The rebleeding rate and secondary injury rate of the observation group were 20.00% and 3.33% respectively, which were significantly lower than 46.67% and 23.33% of the control group, while the success rate of rescue was 100.00% in the observation group, and was significantly higher than 86.67% in the control group(P < 0.05). Conclusion The new non-invasive external fixation device can effectively alleviate the pain of patients with pelvic fractures, reduce the incidence of rebleeding and secondary injuries, and improve the success rate of clinical rescue.