Abstract: Objective To investigate the therapeutic effect of metoprolol combined with atorvastatin calcium in patients with chronic heart failure. Methods A total of 120 patients with chronic heart failure treated in our hospital were selected and randomly divided into two groups. The control group(n=60)was given metoprolol based on routine treatment, and the observation group(n=60)was treated by atorvastatin calcium treatment on the basis of the control group. Cardiac function indexes and plasma high sensitivity C reactive protein(hs-CRP)and adverse reactions before and after treatment in the two groups were compared. Results The total effective rate in the observation group was higher than that in the control group, and the difference was statistically significant(P < 0.05). After treatment, the left ventricular end-systolic diameter(LVEDs), left ventricular end-diastolic volume(EDV)in the observation group were lower than those in the control group, left ventricular ejection fraction(LVEF)was higher than that in the control group, and plasma hs-CRP was lower than that in the control group(P < 0.05). There were no differences in adverse reactions between the two groups(P > 0.05). Conclusion Metoprolol combined with atorvastatin calcium has a significant effect on chronic heart failure, with significant improvement in cardiac function and a decrease in hs-CRP, and no obvious side effects are found.