Abstract: Objective To explore the diagnostic value of blood oxygen saturation(SpO₂)monitoring combined with auscultation murmur monitoring in congenital heart disease. Methods A total of 288 children with suspected congenital heart disease were selected. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of auscultation of murmur alone as well as auscultation of murmur and SpO₂ combined with murmur were compared. Results Among 288 cases, 155 cases were diagnosed as congenital heart disease, among which atrial septal defect, foramen ovale and patent ductus arteriosus ranked the top three, accounting for 45.16%, 26.45% and 17.42% respectively. The sensitivity, accuracy and negative predictive value of SpO₂ combined with murmur auscultation in the diagnosis of congenital heart disease were significantly higher than those of murmur auscultation(P < 0.05). Conclusion SpO₂ combined with murmur auscultation has higher value in the diagnosis of congenital heart disease.