Abstract: Objective To explore the nursing experience of severe right heart failure patients with systemic lupus erythematosus complicated with pulmonary arterial hypertension. Methods Thirty-six patients with systemic lupus erythematosus complicated with pulmonary arterial hypertension were given intravenous infusion of injectable cyclophosphamide, anti-pulmonary artery pressure targeted treatment and special nursing care. Results The clinical symptoms of 34 patients were significantly improved. Eight cases had oral ulcers, and were healed in 5 days after special care. Eleven cases had multiple serous cavity effusion, but disappeared gradually in 10 to 14 days after targeted care. The systolic pressure and diastolic pressure in 4 patients was 72~84 mmHg and 42~50 mmHg respectively at admission, and were increased to 92~118 mmHg and 5~70 mmHg respectively after 4 to 10 days of treatment with heart strengthening and pulmonary vasodilator therapy. 34 patients were all discharged after 14 to 22 days of hospitalization, and 2 patients died. Conclusion Comprehensive treatment and nursing can reduce complications and mortality rate, and improve quality of life in severe right heart failure patients with systemic lupus erythematosus complicated with pulmonary hypertension.