Abstract: Objective To investigate the therapeutic effect of cetirizine drops combined with budesonide inhaler in children with acute asthma attack. Methods A total of 70 children with acute asthma attacks were selected in our hospital and divided into control group(n=35, budesonide aerosol inhalation)and observation group(n=35, cetirizine drops combined with budesonide inhalation)according to randomized double blind method. Efficacy of asthma symptoms remission, pulmonary function and adverse reactions of two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group(97.14%vs. 77.14%), and the maximum air volume(MVV), forced expiratory volume(FEV₁)and forced vital capacity(FVC)after treatment were all higher than that in the control group(P < 0.05). There were no serious adverse reactions in the two groups, the incidence of adverse reactions was 8.57% in the observation group and 14.29%in the control group, but no significant difference was observed(P > 0.05). Conclusion The combination of cetirizine drops and budesonide inhalation in the treatment of acute asthma attack has significant effect, which can improve the children's lung function, and has no obvious adverse reactions.