Abstract: Objective To explore the establishment of nurse-led integrated model of orthopedic rehabilitation after lumbar surgery. Methods A total of 235 patients diagnosed as lumbar degeneration undergoing single segmental lumbar posterior bone graft fusion and internal fixation were divided into control group with 118 cases and observation group with 117 cases of according to the order of admission. The control group implemented the traditional recovery mode, while the observation group implemented nurse-led integrated model of orthopedic rehabilitation. The Oswestry Disability Index(ODI)and Japanese Orthopaedic Association(JOA)score were used to evaluate lumbar function, and Number-rating Scale(NRS)was used to assess the degree of pain before the surgery, at 7 d, 1 month, 3 months, 6 months after operation were compared. Results There were no significant differences in NRS, JOA scores and improved ODI score between the two groups before surgery and at 7 d after surgery(P > 0.05). Scores ofNRS and improved ODI in the observation group were lower than those in the control group at 1, 3 and 6 months after surgery(P < 0.05), and JOA improvement rates at 3 and 6 months after surgery were lower than those in the control group(P < 0.05). Conclusion Nurse-led integrated model of orthopedic rehabilitation can alleviate the postoperative pain of patients undergoing internal fixation of lumbar canal decompressed bone grafting and improve the rate of lumbar function.