Abstract: Objective To explore the clinical value of self-fixed patch in laparoscopic inguinal hernia repair and open tension-free inguinal hernia repair. Methods The clinical materials of 80 patients with inguinal hernia were analyzed, and they were divided into open group(treated with open tension-free inguinal hernia repair)and laparoscopic group(treated with laparoscopic totally extra-peritoneal repair), with 40 cases in each group. Postoperative recovery indicators and postoperative complications were compared between the two groups. Results The patients in the laparoscopic group had a earlier time of bed-off activities, a shorter hospitalization time and a lower Visual Analogue Scale(VAS)score at 24 h after operation than those in the open group(P<0.05). There were no significant differences in the incidence rates of foreign body sensation and chronic pain between the two groups(P>0.05). The incidence of scrotal hematoma in the laparoscopic group was significantly lower than that in the open group(P<0.05). Conclusion The application of self-fixed patch in laparoscopic inguinal hernia repair has a better overall effect compared to open tension-free inguinal hernia repair, which is beneficial to relieve postoperative pain and shorten postoperative hospital stay.