Abstract: Objective To explore the clinical effects of dizocine combined with midazolam or with fentanyl in the prevention and treatment of gastric stretch pain and shivering in cesarean section under lumbar-epidural anesthesia. Methods A total of 120 cesarean section puerperas under lumbar-epidural anesthesia were randomly divided into 3 groups, with 40 cases in each group. Immediately after the birth of the fetus, group A received 0.10 mg/kg of intravenous infusion of dizocine, and group B received 0.10 mg/kg of intravenous infusion of dizocine as well as 0.03 mg/kg of midazolam, and group C received 0.10mg/kg of intravenous infusion of dizocine as well as fentanyl for 0.1 mg. The changes of noninvasive arterial blood pressure(NIBP), heart rate(HR), respiratory rate(RR), blood oxygen saturation(SpO₂)were observed in the parturient women immediately after drug intravenous infusion, The Ramsay score and stomach-stretching pain score and shivering before drug administration(T₀), at 5 min(T₁), 30 min(T₂)and 60 min(T₃)after drug administration were observed. Results There were no significant differences in NIBP, HR, RR SpO₂ among three groups(P>0.05). The incidence of adverse reactions was 2.5% in A group, 2.5% in group B, and 12.5% in group C, but no significant differences were observed(P>0.05). The Wrench shivering scores at T₁, T₂ and T₃ in groups B and C were lower than group A(P<0.05). The Ramsay sedation scores at T₁, T₂ and T₃ in three groups showed significant differences(P< 0.05). At T₁, T₂ and T₃, Visual Analogue Scale(VAS)score in group C and group B was significantly lower than that - of group A(P<0.05). Conclusion Dizocine combined with midazolam or with fentanyl, with less adverse reaction, can reduce the degree of gastric stretch pain and shivering reaction during cesarean section, and can stabilize the respiratory and circulatory system of puerperas, maintain longer time in analgesia and better satisfaction in analgesia efficacy, and has a milder sedation.