Abstract: Objective To investigate the effect of nasal endoscopy combined with laryngeal dynamic system in the treatment of benign vocal cord lesions patients with difficulty of glottis exposure. Methods A total of 84 vocal cord benign lesions patients with difficulty of glottis exposure were divided into two groups according to surgical methods. The observation group(n=50)was treated by laryngeal dynamic system resection under nasal endoscopy and support laryngoscope, while the control group(n=34)was treated with conventional support laryngoscope microsurgery. The operation time, clinical efficacy and incidence of complications were compared between the two groups. Results The operation time of the observation group was(44.62±10.25)min, which was significantly shorter than(50.39±13.34)min of the control group(P<0.05). There were no significant differences in the score of each item and the total score of voice disorder index-10(VHI)scale before operation between the two groups(P>0.05). Compared with scores before operation, the score of each item and the total score of VHI decreased significantly at 4 weeks after the operation in both groups, and the decrease range of the observation group was significantly greater than that of the control group(P<0.05). The total incidence of postoperative complications in the observation group was 10.00%, which was significantly lower than 23.53% in the control group(P<0.05). The total - effective rate of the observation group was 98.00%, which was significantly higher than 82.35% of the control group(P<0.05). The cure rate of the observation group was 90.00%, which was significantly higher than 58.82% of the control group(P<0.05). Conclusion Nasal endoscopy combined with laryngeal dynamic system is safe and effective in the treatment of vocal cord benign lesions patients with difficulty of glottis exposure, which has the advantages of clear vision, simple operation, less trauma, less complications and high cure rate.