Abstract: Objective To investigate the clinical effect of continuous block with catheterization in the anterior space of epidural space combined with lumbar low temperature plasma ablation in treatment of patients with discogenic low back pain. Methods A total of 106 patients with discogenic low back pain were selected and divided into two groups according to the treatment plan. The control group was treated with continuous block with catheterization in the anterior space of epidural space, while the observation group was treated with continuous block with catheterization in the anterior space of epidural space combined with lumbar low temperature plasma ablation. The NRS scores(before operation, 1 week after operation, 1 month after operation, 3 months after operation), the modified Macnab scores(before operation, 1 month after operation, 3 months after operation), the M-JOA scores(before operation, 1 month after operation, 3 months after operation)and the levels of interleukin-1(IL-1)and interleukin-6(IL-6)(before operation, 1 month after operation, 3 months after operation)were compared between the two groups. Results There were no significant difference in NRS scores between the two groups before operation and 1 week after operation(P>0.05). The NRS scores of the observation group were significantly lower than those of the control group at 1 and 3 months after operation(P<0.05). The excellent and good rates of Macnab in the observation group - were significantly higher than those in the control group at 1 and 3 months after operation(P<0.05). At 1 and 3 months after operation, the M-JOA scores of the observation group were significantly higher than those of the control group(P<0.05). The serum levels of IL-1 and IL-6 in the observation group were significantly lower than those in the control group(P<0.05). Conclusion Continuous block with catheterization in the anterior space of epidural space combined with lumbar low temperature plasma ablation is effective and safe in treatment of patients with discogenic low back pain, which can reduce serum IL-1 and IL-6 levels.