Abstract: Objective To compare the effect between meropenem administration with two-step pumping method for prolonging the administration time to 3 h and the traditional meropenem administration for 30 min on the clinical efficacy of patients with severe infection. Methods A total of 40 patients with severe infection in the Intensive Care Unit(ICU)were selected and randomly divided into extended administration group(administration with two-step pumping method)and traditional administration group. The body temperature, white blood cell count, procalcitonin(PCT), and Sequential Organ Failure Assessment(SOFA)score at one day before administration and 4 days after administration were recorded, and clearance rate of pathogenic bacteria on the 7^th day of administration, adverse reactions and the cure rate on the 28^th day of follow-up were compared between two groups. Results After treatment, the body temperature, WBC, PCT level and SOFA score of the extended administration group were significantly lower than those of the traditional administration group, while clearance rate of pathogenic bacteria and cure rate were significantly higher than those of the traditional administration group(P<0.05). No adverse reactions occurred during administration in both groups. Conclusion The clinical efficacy of meropenem administration with two-step pumping method is better than the traditional administration method, which is more helpful for the treatment and recovery of patients, and the safety is good.