Efficacy and safety of flunarizine hydrochloride in the prophylactic treatment of vestibular migraine
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摘要: 目的 探讨盐酸氟桂利嗪在前庭性偏头痛(VM)预防性治疗中的效果。 方法 将160例VM患者随机分为对照组(应用甲磺酸倍他司汀治疗)与实验组(应用盐酸氟桂利嗪预防治疗联合甲磺酸倍他司汀治疗)各80例。随访3个月,比较2组总有效率、眩晕累计发作时间、眩晕累计发作次数、眩晕强度评分、脑血流速度、睡眠质量评分、生活质量评分及不良反应发生率。 结果 实验组总有效率95.00%, 显著高于对照组80.00%(P<0.05)。实验组治疗后眩晕累计发作时间、眩晕累计发作次数、眩晕强度评分均显著优于对照组(P<0.05)。实验组治疗后睡眠质量评分显著低于对照组(P<0.05), 生活质量评分显著高于对照组(P<0.05)。实验组治疗后大脑前动脉、大脑中动脉、大脑后动脉及基底动脉平均血流速度显著低于对照组(P<0.05)。对照组不良反应发生率为8.75%, 实验组不良反应发生率为13.75%。2组不良反应发生率比较无显著差异(P>0.05)。 结论 对VM患者实施盐酸氟桂利嗪治疗具有较好的预防效果,可有效减少眩晕发作次数及强度,且安全性较好。Abstract: Objective To explore the effect of flunarizine hydrochloride in the prophylactic treatment of vestibular migraine(VM). Methods Totally 160 patients with VM were randomly divided into control group(treated with betahistine mesylate)and experimental group(treated with flunarizine hydrochloride and betahistine mesylate), with 80 cases in each group. After 3 months of follow-up, the total effective rate, cumulative attack time of vertigo, cumulative attack times of vertigo, vertigo intensity score, cerebral blood flow velocity, sleep quality score, life quality score and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the experimental group was 95.00%, which was significantly higher than 80.00% of the control group(P<0.05). After treatment, cumulative attack time of vertigo, cumulative attack times of vertigo and vertigo intensity score in the experimental group were significantly better than those in the control group(P<0.05). The sleep quality score of the experimental group was significantly lower than that of the control group(P<0.05), and the life quality score was significantly higher than that of the control group(P<0.05). After treatment, the average blood flow velocities of anterior cerebral artery, middle cerebral artery, posterior cerebral artery and basilar artery in the experimental group were significantly lower than those in the control group(P<0.05). The incidence of adverse - reactions was 8.75% in the control group and 13.75% in the experimental group, and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion Flunarizine hydrochloride has a good prophylactic therapeutic effect in the treatment of patients with VM, which can effectively reduce the frequency and intensity of vertigo attack, and the safety is good.
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