Abstract: Objective To study the value of pediatric critical score in evaluating the prognosis of children in pediatric intensive care unit(PICU). Methods The clinical data of 80 cases in PICU treated in our hospital were retrospectively analyzed. The children were divided into group A(extremely critical children), group B(critical children)and group C(non-critical children)according to the critical score at 24 hours after admission. The hospitalization time, rescue times, the incidence of multiple organ failure(MOSF), the number of organs with functional failure, the incidence of complications and the 28-day mortality rate were compared among the three groups. Results The hospitalization time in PICU, rescue times, incidence of MOSF, number of organs with functional failure, incidence of complications and 28-day mortality in group A were higher than those in group B and C(P<0.05), and group B was better than group C in above indicators(P<0.05). Conclusion Children's critical score is of great value in prediction of the severity and prognosis of PICU children. It is necessary to strengthen the monitoring of children with critical score and related nursing in clinical work in order to reduce the mortality rate.