Abstract: Objective To investigate the effect of comprehensive management on blood sugar level, delivery outcomes and fetus of pregnant women with gestational impaired glucose tolerance. Methods A total of 120 pregnant women with gestational impaired glucose tolerance diagnosed in our hospital were selected and divided into two groups according to random number table method. The control group(n=60)was given routine prenatal examination, pregnancy education, and nutrition guidance, while the observation group(n=60)received the comprehensive management based on the control group. The blood glucose level, weight changes, complications, pregnancy outcomes and fetal status of pregnant women in different periods were compared between the two groups. Results The fasting blood glucose and postprandial 2 h blood glucose, and pregnancy body mass between the two groups showed no differences at the admission time(P>0.05). The observation group had lower postprandial 2 h blood glucose, and pregnancy body mass after delivery than the control group at the 32, 36 and 40 gestational weeks(P<0.05). The incidences of pregnancy hypertension, preterm delivery and premature rupture of membranes in the observation group were lower than that in the control group(P<0.05). The incidence of natural childbirth in the observation group was higher, and the neonatal body mass was better than that in the control group(P<0.05). Conclusion Comprehensive management can effectively improve the postprandial 2 h blood glucose level, control the changes of body weight, reduce the incidence of complications, and improve the delivery rate of pregnant women and safety of the fetus.