Abstract: Objective To analyze the changes of lymphocyte, interleukin-6(IL-6)and inflammatory indexes in patients with coronavirus disease 2019(COVID-19)under different conditions of disease in northeast division of Chongqing. Methods A total of 74 patients with COVID-19 in Chongqing Three Gorges Central Hospital from January 28, 2020 to February 21, 2020 were selected, which including 27 severe cases, 18 critical cases and 29 mild cases. They were divided into five groups according to theirdisease status, among whom the critically ill patients were divided into groups A, B, C and D, and the mild ill patients into group E. Some patients were counted several times due to disease progression. Flow cytometer and blood routine analyzer were used to detect the levels of lymphocyte, IL-6 and inflammatory indexes in patients with different conditions of disease. Results The levels of IL-6 and C reactive protein(CRP)in severe patients with different conditions of disease were - significantly higher than those in mild patients(P<0.01), and the level of IL-6 in group A［patients with endotracheal intubation, extracorporeal membrane oxygenation(ECMO)and pre-death status］was significantly higher than that in the other four groups(P<0.05). The more severe the dyspnea was, the lower the lymphocyte count, T-lymphocyte, B-lymphocyte, CD4⁺T and CD8⁺T levels were, and there were significant differences between severe patients with different conditions and mild patients(P<0.05). The more severe the dyspnea symptom was, the lower the lymphocyte ratio was, and there was a significant difference between group A and other groups(P<0.01). There was no significant difference in procalcitonin among five groups(P>0.05). Conclusion IL-6, lymphocyte and CRP can predict the change of coronavirus disease 2019.