Abstract: Objective To compare the effect of CAD/CAM zirconia post core and fiberglass post and resin core in treatment of patients with restoration of maxillary anterior teeth. Methods A total of 104 patients with restoration of maxillary anterior teeth were divided into two groups, with 52 cases in each group. Control group was treated with CAD/CAM zirconia post and core, while study group was treated with fiberglass post and resin core. The success rate of restoration, the excellent rate of masticatory function, the intensity of fracture resistance and the index of gingival bleeding were compared between the two groups. Results The success rate of restoration in the study group was 90.38%, which was significantly higher than 75.00% in the control group(P<0.05). The excellent rate of masticatory function within one year after operation in the study group was 96.15%, which was significantly higher than 82.69% in the control group(P<0.05). After treatment, the intensity of fracture resistance was significantly higher than that before treatment in both groups, and the study group was significantly higher than the control group(P<0.05). After treatment, the index of gingival bleeding was significantly lower than that before treatment in both groups, and the study group was significantly lower than the control group(P<0.05). Conclusion Compared with the CAD/CAM zirconia post core, the fiberglass post and resin core has a higher success rate of restoration, a higher excellent rate of masticatory function, and better intensity of fracture resistance and index of gingival bleeding.