Abstract: Objective To explore the effect of duloxetine hydrochloride as well as Shunfeng Yunqi Decoction combined with Yueju Pill on Hamilton Depression Scale(HAMD)and National Institutes of Health Stroke Scale(NIHSS)in patients with post cerebral infarction depression. Methods A total of 80 patients with post cerebral infarction depression diagnosed and treated in the hospital were selected as research subjects, and were divided into two groups according to different treatment plans. The patients treated with duloxetine hydrochloride alone were selected as control group(n=40), those additionally treated with Shunfeng Yunqi Decoction and Yueju Pill were selected as study group(n=40). The depression symptoms, degree of functional defect and the change of neurotransmitter of the two groups before and after treatment were analyzed. Results After 6 weeks of treatment, the HAMD scores, and NIHSS scores of the two groups were lower than before treatment(P<0.05), and the study group was lower than the control group(P<0.05); after treatment, the levels of 5-hydroxytryptamine(5-HT)and endothelin(ET)in the study group and the control group were higher than those before treatment(P<0.05), and the levels of above indicators in the study group were higher than those in the control group(P<0.05). Conclusion Duloxetine hydrochloride and Shunfeng Yunqi Decoction combined with Yueju Pill has better clinical effect in the treatment of post cerebral infarction depression, which can effectively relieve the depressive symptoms, improve the related indicators of neurotransmitters, and reduce neurological deficit.