Abstract: Objective To compare the effect of sequential enteral nutrition and parenteral nutrition in patients with severe cerebral hemorrhage. Methods Eighty-four patients with severe cerebral hemorrhage treated in our hospital were selected and divided into two groups according to digital parity method. The control group(n=42)was given parenteral nutrition, while the observation group(n=42)was used sequential enteral nutrition. Nerve function, nutritional indicators, and incidence of complications before and after treatment were compared between the two groups. Results The levels of hemoglobin(Hb), prealbumin(PAB), albumin(Alb)after 2-week treatment in the observation group were higher than that in the control group, and the body weight, triceps skin fold(TSF), and mid arm muscle circumference(MAMC)were higher than those in the control group(P<0.05). The observation group had lower National Institutes of Health Stroke Scale(NIHSS)score at 2 weeks after treatment than the control group［(11.48 ± 5.61)vs.(17.49 ± 6.28), P<0.05］. The complication rate was lower than that in the control group, the difference was statistically significant(21.43% vs. 50.00%, P<0.05). Conclusion Compared with parenteral nutrition, sequential enteral nutrition can promote intestinal recovery and improve the nutritional status of patients.