Objective  To observe the therapeutic effect of adaptive radiation therapy (ART) in patients with locally advanced cervical cancer.

  Methods  A total of 85 patients with locally advanced cervical cancer were randomly divided into control group (n=42) and observation group (n=43). Patients in both groups received conventional chemotherapy, the control group was combined with external exposure of inverse intensity modulated radiation therapy (IMRT), and the observation group was combined with ART. After treatment, the clinical efficacy, the dosemetry level of organ at risk and the incidence of adverse reactions in two groups were compared.

  Results  After treatment, the total effective rate of the observation group was significantly higher than that of the control group (P < 0.05); at the end of 8 weeks of treatment, the dosimetry level of organs at risk in the observation group was significantly lower than that in the control group (P < 0.05); the incidence of adverse reactions in observation group was significantly lower than that in the control group (P < 0.05).

  Conclusion  ART in patients with locally advanced cervical cancer has a significant effect, which can relieve peripheral tissue damage, decrease the incidence of adverse reactions and improve the prognosis of patients.