Abstract: Objective To retrospectively analyze the changes of myocardial enzymes and routine blood test in 248 patients with coronavirus disease 2019(COVID-19)under different disease status in the northeast area of Chongqing. Methods A total of 248 patients with COVID-19 in Chongqing Three Gorges Central Hospital from January 1, 2020 to February 21, 2020 were selected. A total of 45 severe and critically ill patients and 29 mild ill cases were randomly selected from the rest of 203 patients. At last, 74 cases with COVID-19 in total were included in the study, and were divided into five groups according to their disease status, among whom the critically ill patients were divided into groups A, B, C and D, and the mild ill patients into group E. Some patients were counted several times due to disease progression. Flow cytometry, myocardial enzyme spectrometry and blood routine analyzer were used to detect myocardial enzyme spectrometry［troponin kinase(CK), troponin kinase isoenzyme(CK-MB), α-hydroxybutyrate dehydrogenase(α-HBDH)］and blood routine indicators(lymphocyte ratio,white blood cell count, neutrophil ratio)in COVID-19 patients in - groups A, B, C, D and E. Results The severer the patients with COVID-19 were, the higher values of CK, CK-MB and α-HBDH will be, and the highest values of above indicators occurred in the severest patients in group A. The neutrophil ratios in groups A, B, C and D were all higher than the upper limit of normal value, and the leukocyte count in group A was significantly higher than the other four groups and its mean value was much higher than normal value. The mean value of lymphocyte ratio was lower in the severer ill patients with COVID-19, with group A having the lowest and much lower ratio than normal value. Conclusion Severe patients with COVID-19 often complicate varying degrees of alterations in blood routines and myocardial enzyme profiles.