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桔芩汤对痰热壅肺型支气管扩张患者的血清促炎因子、氧自由基及肺功能的影响

孙锦贤, 余静珠, 屠春林, 胡建荣, 朱丽萍, 高强

孙锦贤, 余静珠, 屠春林, 胡建荣, 朱丽萍, 高强. 桔芩汤对痰热壅肺型支气管扩张患者的血清促炎因子、氧自由基及肺功能的影响[J]. 实用临床医药杂志, 2020, 24(7): 23-26. DOI: 10.7619/jcmp.202007007
引用本文: 孙锦贤, 余静珠, 屠春林, 胡建荣, 朱丽萍, 高强. 桔芩汤对痰热壅肺型支气管扩张患者的血清促炎因子、氧自由基及肺功能的影响[J]. 实用临床医药杂志, 2020, 24(7): 23-26. DOI: 10.7619/jcmp.202007007
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SUN Jinxian, YU Jingzhu, TU Chunlin, HU Jianrong, ZHU Liping, GAO Qiang. Efficacy of Jieqin Decoction on serum proinflammatory factors, oxygen free radical and pulmonary function in patients with bronchiectasis differentiated as type of phlegm-heat obstructing lung[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 23-26. DOI: 10.7619/jcmp.202007007
Citation: SUN Jinxian, YU Jingzhu, TU Chunlin, HU Jianrong, ZHU Liping, GAO Qiang. Efficacy of Jieqin Decoction on serum proinflammatory factors, oxygen free radical and pulmonary function in patients with bronchiectasis differentiated as type of phlegm-heat obstructing lung[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 23-26. DOI: 10.7619/jcmp.202007007
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桔芩汤对痰热壅肺型支气管扩张患者的血清促炎因子、氧自由基及肺功能的影响

  • 1. 上海健康医学院附属嘉定区中心医院, 上海, 201800;

  • 2. 上海市嘉定区迎园医院, 上海, 201822

基金项目: 

上海市嘉定区农业和社会事业科研项目(JDKW-2017-W17)

上海市嘉定区卫生计生系统医学重点学科项目(2017-ZD-05)

详细信息
    通讯作者:

    余静珠,E-mail:15026676525@163.com

  • 中图分类号: R562.2

Efficacy of Jieqin Decoction on serum proinflammatory factors, oxygen free radical and pulmonary function in patients with bronchiectasis differentiated as type of phlegm-heat obstructing lung

  • 1. Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, 201800;

  • 2. Yingyuan Hospital in Jiading District, Shanghai, 201809

摘要

    摘要
  • 摘要: 目的 观察桔芩汤对痰热壅肺型支气管扩张稳定期患者血清促炎因子、氧自由基及肺功能的影响。 方法 将上海健康医学院附属嘉定区中心医院符合痰热壅肺型中医诊断标准的70例支气管扩张稳定期患者随机分为对照组、实验组,每组各35例。对照组采用西医常规治疗,实验组在西医常规治疗的基础上加用中药桔芩汤治疗,疗程均为30 d。比较2组治疗前后促炎因子、氧自由基及肺功能的变化。 结果 治疗后, 2组血清白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)水平均显著降低(P<0.01), 且实验组显著低于对照组(P<0.05); 实验组超氧化物歧化酶(SOD)水平显著升高(P<0.05)。治疗后, 2组肺通气功能［用力肺活量占预计值的百分比(FVC%pred)、第1秒用力呼气容积占预计值的百分比(FEVl%pred)、第1秒用力呼气容积占用力肺活量百分比(FEVl/FVC)］ 较治疗前显著改善(P<0.01), 实验组改善程度较对照组更显著(P<0.05); 治疗后,实验组肺换气功能［一氧化碳弥散量占预计值百分比(DLCO%pred)、单位肺泡容积的一氧化碳弥散量占预计值百分比(DLCO/VA%pred)较治疗前改善显著(P<0.05), 但2组差异无统计学意义(P>0.05)。 结论 桔芩汤结合西医常规治疗既能缓解支气管扩张患者炎症及过氧化状态,又能部分阻止或减缓肺功能下降。
    Abstract: Objective To observe the effect of Jieqin Decoction on serum proinflammatory factors, oxygen free radical and pulmonary function in patients with stable stage bronchiectasis differentiated as phlegm-heat obstructing lung. Methods A total of 70 patients with stable stage bronchiectasis differentiated as type of phlegm-heat obstructing lungs were randomly divided into experimental group and control group, with 35 cases in each group. Both groups were treated with conventional western medication, while Jieqin Decoction was added in the experimental group. The treatment course lasted for 30 days. Comparison of proinflammatory factors, oxygen free radical and pulmonary function before and after treatment in both groups were performed. Results After treatment, serum interleukin-8(IL-8), tumor necrosis factor-α(TNF-α)and malondialdehyde(MDA)levels were significantly decreased in the two groups(P<0.01), and the experimental group was significantly lower than the control group(P<0.05). Superoxide dismutase(SOD)level increased significantly only in the experimental group(P<0.05). After treatment, the pulmonary ventilation function indicators ［percentage of forced vital capacity to the predicted normal value(FVC%pred), percentage of forced expiratory volume in the first second to the predicted normal value(FEVl%pred), percentage of forced - expiratory volume in the first second to forced vital capacity(FEVl/FVC)］of the two groups were significantly improved compared with the treatment before(P<0.01), and the improvement of the experimental group was more significant than that of the control group(P<0.05). The improvement of pulmonary ventilation function［percentage of carbon monoxide dispersion to predicted value(DLCO%pred), and percentage of carbon monoxide dispersion per alveolar volume to expected value(DLCO/VA%pred)was more obvious in the experimental group after treatment compared with treatment before(P<0.05), but there was no significant difference between the two groups(P>0.05). Conclusion Combining conventional western medicine and Jieqin Decoction can not only relieve inflammation and peroxidation in patients with bronchiectasis, but also partially prevent or slow down the decline of pulmonary function.
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    • 参考文献(16)
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  • 收稿日期:  2019-12-24

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