Effect of levofloxacin combined with Bailing Capsule in the treatment of lower respiratory tract infection in hemodialysis patients with chronic renal failure
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摘要: 目的 探讨慢性肾衰竭行血液透析后合并下呼吸道感染的患者应用左氧氟沙星联合百令胶囊治疗的效果。 方法 选取62例行血液透析治疗的慢性肾衰竭伴下呼吸道感染患者作为研究对象,随机分成实验组与对照组各31例。对照组单用左氧氟沙星进行抗感染治疗,实验组采用左氧氟沙星联合百令胶囊治疗,对比2组治疗效果。 结果 实验组总有效率为93.55%, 显著高于对照组的74.19%(P<0.05); 治疗后, 2组尿素氮(BUN)、血肌酐(Scr)、肌酐清除率(Ccr)均显著改善,而实验组指标变化较对照组更显著(P<0.05); 治疗后, 2组CD3+、CD4+、CD8+、CD4+/CD8+水平均较治疗前提高,且实验组CD3+、CD4+、CD8+、CD4+/CD8+水平显著高于对照组(P<0.05)。 结论 慢性肾衰竭血液透析患者下呼吸道感染应用左氧氟沙星联合百令胶囊治疗能取得满意效果,可改善患者肾功能及免疫功能。Abstract: Objective To investigate the effect of levofloxacin combined with Bailing Capsule in the treatment of lower respiratory tract infection in patients with chronic renal failure after hemodialysis. Methods Sixty-two patients with chronic renal failure complicated with lower respiratory tract infection after hemodialysis were randomly divided into experimental group(n=31)and control group(n=31). The control group was treated with levofloxacin alone for anti-infective treatment. The experimental group was treated with levofloxacin combined with Bailing Capsule. The treatment effects of the two groups were compared. Results The total effective rate of the experimental group was 93.55%, which was significantly higher than 74.19% in the control group(P<0.05). After treatment, the blood urea nitrogen(BUN), serum creatinine(Scr)and creatinine clearance rate(Ccr)were significantly improved, and the experimental group changed more significantly than the control group(P<0.05). After treatment, the levels of CD3+, CD4+, CD8+, and CD4+/CD8+ were all increased in the two groups, and the experimental group was significantly higher than the control group(P<0.05). Conclusion For patients with chronic renal failure and lower respiratory tract infection, the application of levofloxacin combined with Bailing Capsule can achieve satisfactory results, and can improve patients' renal and immune functions.
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