Abstract: Objective To explore effect of minimally invasive surgery in patients with space-occupying lesions of left hepatic lobe. Methods A total of 84 patients treated in our hospital were selected as research objects. According to random number table method, the patients were divided into two groups by random number table method, among whom 42 patients who underwent laparoscopic hepatectomy were selected as observation group and 42 patients who underwent conventional open hepatectomy were selected as control group. The operative time, incision length, hospital stay and drainage tube indwelling time were compared between the two groups. The levels of alanine aminotransferase, aspartate aminotransferase, and bilirubin in the two groups were recorded, and the total incidence of complications in the two groups was compared. Results The operation time in the observation group was significantly longer than that in the control group(P<0.05). The incision length, length of hospital stay, and drainage tube indwelling time in the observation group were significantly shorter than those in the control group(P<0.05). The levels of alanine aminotransferase, aspartate aminotransferase, and bilirubin in the observation group were significantly lower than those in the control group(P<0.05). The total incidence of complications in the observation group was significantly lower than that in the control group(P<0.05). Conclusion Laparoscopic hepatectomy is effective in the treatment of space-occupying lesions of left hepatic lobe. It can shorten the hospitalization time and promote the recovery of patients, and has the advantages of minimally invasive and quick recovery. At the same time, laparoscopic hepatectomy with higher safety can significantly reduce the incidence of complications in patients with space-occupying lesions of left hepatic lobe.