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食管癌组织中溶酶体相关膜蛋白2a的表达及其临床意义

闵燕飞, 黄荣, 蒋军, 何瀚

闵燕飞, 黄荣, 蒋军, 何瀚. 食管癌组织中溶酶体相关膜蛋白2a的表达及其临床意义[J]. 实用临床医药杂志, 2020, 24(7): 72-76. DOI: 10.7619/jcmp.202007021
引用本文: 闵燕飞, 黄荣, 蒋军, 何瀚. 食管癌组织中溶酶体相关膜蛋白2a的表达及其临床意义[J]. 实用临床医药杂志, 2020, 24(7): 72-76. DOI: 10.7619/jcmp.202007021
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MIN Yanfei, HUANG Rong, JIANG Jun, HE Han. Expression of lysosomal associated membrane protein 2a in tissue of esophageal cancer and its clinical significance[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 72-76. DOI: 10.7619/jcmp.202007021
Citation: MIN Yanfei, HUANG Rong, JIANG Jun, HE Han. Expression of lysosomal associated membrane protein 2a in tissue of esophageal cancer and its clinical significance[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 72-76. DOI: 10.7619/jcmp.202007021
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食管癌组织中溶酶体相关膜蛋白2a的表达及其临床意义

  • 广东省佛山市第一人民医院 胸腹放疗科, 广东 佛山, 528000

基金项目: 

广东省佛山市卫生和计划生育局医学科研课题(20190043)

详细信息

  • 中图分类号: R735.1

Expression of lysosomal associated membrane protein 2a in tissue of esophageal cancer and its clinical significance

  • Department of Chest and Abdomen Radiotherapy, Foshan City First People's Hospital, Foshan, Guangdong, 528000

摘要

    摘要
  • 摘要: 目的 探讨溶酶体相关膜蛋白2a(LAMP2a)在食管癌组织中的表达及其临床意义。 方法 采用免疫组织化学方法检测58例患者的食管癌组织标本和30例正常食管组织中LAMP2a的表达水平,分析其与临床病理特征的相关性。 结果 LAMP2a在食管癌组织中呈显著高表达,与肿瘤临床分期(P<0.001)、T分期(P=0.043)及分化程度(P=0.018)密切相关,与性别(P=0.740)、年龄(P=0.590)和淋巴结转移(P=0.188)无显著相关性; LAMP2a表达水平与患者的预后呈负相关(P<0.05); Cox比例风险模型显示,肿瘤浸润深度和LAMP2a蛋白表达是食管癌患者独立影响因素(P<0.05)。 结论 LAMP2a的表达可成为肿瘤早期诊断及预后状况评估的有效指标。
    Abstract: Objective To investigate the expression of lysosomal associated membrane protein 2a(LAMP2a)in tissue of esophageal cancer and its clinical significance. Methods The expressions of LAMP2a in 58 specimens of esophageal cancer and 30 specimens of normal esophageal tissues were detected by immunohistochemical methods, and its correlation with clinicopathological features was analyzed. Results The expression of LAMP2a was significantly higher in esophageal cancer tissues, which was closely correlated to tumor clinical staging(P<0.001), T staging(P=0.043)and differentiation degree(P=0.018), but no correlation with gender(P=0.740), age(P=0.590)and lymph node metastasis(P=0.188); the expression of LAMP2a was negatively correlated with the prognosis of patients(P<0.05). Cox proportional hazard model showed that depth of invasion and expression of LAMP2a protein were independent risk factors for esophageal cancer(P<0.05). Conclusion The expression of LAMP2a can be used as an effective indicator in early diagnosis and prognosis evaluation of tumors.
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  • 收稿日期:  2019-12-12

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