Abstract: Objective To investigate the expression and significance of chemokine C-C-receptor 4(CCR4)in colorectal cancer. Methods Totally 80 surgical specimens of primary colorectal cancer were selected as group A, and 75 patients with benign colorectal cancer were selected as group B. The positive detection rates of CCR4 in colorectal cancer and benign colorectal cancer were compared. The positive rates of CCR4 in colorectal cancer and benign colorectal cancer were compared. The relationship between clinicopathological factors and positive results of chemokine receptor CCR4 in colorectal cancer were analyzed. Results The number of positive cases detected by immunohistochemistry, the number of positive cases detected by RT-PCR and the gray ratio of PCR bands in group A were significantly higher than those in group B(P<0.05). In colorectal cancer(group A), there were no significant differences in CCR4 positive test results in gender, age, lymph node metastasis, liver metastasis, differentiation degree, location and other clinical pathological factors(P>0.05), and there were significant differences in CCR4 positive test results in Duke stage(P<0.05). Conclusion The abnormal expression of CCR4 in colorectal cancer may contribute to tumor-induced immunosuppression.