Abstract: Objective To analyze effect of mind mapping guided nursing intervention on positron emission tomography-computed tomography(PET-CT)examination of tumor patients. Methods A total of 100 tumor patients who underwent PET-CT examination were selected as study objects. According to the method of random number table, they were divided into control group(n=50)and observation group(n=50). The control group was given routine nursing, and the observation group received mind mapping guided nursing intervention. PET-CT image quality and examination as well as guidance satisfaction of two groups were observed. Results The excellent rate of imaging in the observation group was significantly higher than that in the control group( 96.0% vs. 80.0%, P<0.05). Scores of nurses'guidance attitude, timely guidance, correct guidance and total scores of the observation group were(4.72±0.73),(4.92±0.85),(4.79±0.21),(12.89±1.34)points respectively, and were significantly higher than(3.67±0.78),(4.04±0.59),(4.23±0.62),(12.18±1.28)points in the control group(P<0.05). The scores of physical symptoms, psychological status and rehabilitation in the observation group were(89.62±7.57),(92.35±6.63),(88.82±6.23)points respectively, which were significantly higher than(79.62±8.92),(82.35±6.64),(85.63±5.86)points in the control group(P<0.05). Conclusion Mind mapping guided nursing intervention can significantly improve the imaging quality of PET-CT examination of tumor patients, and enhance satisfaction of nurse guidance.