Abstract: Objective To investigate application effect of rapid rehabilitation nursing in colonoscopic polypectomy. Methods A total of 180 patients undergoing colonoscopic polypectomy were selected and divided into observation group and control group, with 90 cases per group. The control group received routine operating room nursing, and the observation group additionally given rapid rehabilitation nursing concept based on the control group. The surgical conditions, changes in vital signs, and nursing satisfaction were compared between the two groups. Results The success rate and incidence of postoperative complications in the two groups showed no statistically significant differences(P>0.05). The observation group had shorter operative time, and lower intraoperative systolic blood pressure(SBP), diastolic blood pressure(DBP)and heart rate(HR)than the control group(P<0.05). The surgical nursing satisfaction of the observation group was higher than that of the control group(P<0.05). Conclusion Colonoscopic polypectomy can improve the coordination efficiency of colonoscopic polypectomy, reduce physiological stress response and improve nursing satisfaction.