Abstract: Objective To investigate the effect of Urinary Kallidinogenase for Injection on nervous function in patients with acute cerebral infarction. Methods Totally 50 patients with acute cerebral infarction were divided into two groups. The control group(n=25)was treated with edaravone alone, and the study group(n=25)was treated with Urinary Kallidinogenase for Injection. The neurological function, antioxidant factors, inflammatory factors and cerebrovascular reserve function before and after treatment were compared between the two groups. Results After treatment, the National Institutes of Health Stroke Scale(NIHSS)scores of both groups were significantly lower than that before treatment, and the NIHSS scores of the study group were significantly lower than that of the control group(P<0.05). After treatment, the levels of superoxide dismutase(SOD)in both groups significantly increased, interleukin-6(IL-6)level significantly decreased, and the levels of SOD and IL-6 in the study group were significantly better than that of the control group(P<0.05). After treatment, the levels of neurotrophic factor(NTF)and nerve growth factor(NGF)were significantly higher in both groups than those before treatment, and the indexes in the study group were significantly higher than the control group(P<0.05). Conclusion Urinary Kallidinogenase for Injection has a good therapeutic effect in treating patients with acute cerebral infarction, which can restore the nerve function of patients, improve the cerebrovascular reserve function, and play an anti-inflammatory role.